CCND1

CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.
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Expression of Wnt pathway target genes was detected, including Myc, TCF4, and CCND1, which were all inhibited after regulating LINC00261 (Figure 6C).
According to the company, the 17 fusions include ALK, AXL, BRAF, CCND1, FGFR1, FGFR2, FGFR3, MET, NGR1, NTRK1, NTRK2, NTRK3, PPARG, RAF1, RET, ROS1 as well as THADA.
30) Other recurrent chromosomal alterations have been inconsistently seen in LCIS and include losses of 17q (home of ERBB2 and NF1), 17p (home of TP53), 16p (home of CCNF [cyclin F]), 13q (home of RB [RB binding protein]), 12q, 11q (home of CCND1 (cyclin D1), MEN1 [multiple endocrine neoplasia 1], and ATM [ATM serine/threonine kinase]), 9p, and 8p and gains of 6p and 8p.
Increasing numbers of studies have demonstrated that the garbled expression of microRNAs triggers tumour cell proliferation, apoptosis and differentiation by mediating expression of genes such as P53, MYCN, and CCND1.
Among them, at least HES1, EGR1, JUN, JUNB, CDKN1A, CSF2, CCND1, HMGA2, and SERPINB5 have been associated with hematological neoplasia (see Tables 3 and 4).
Primers and FAM-MGB probes were designed using Primer3 (22) for ERBB2, MYC, NODAL modulator 2 (NOMO2), CCND1, and FGFR1 (see online Supplemental Table 3).
Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, [beta]-catenin, EGFR, and CCND1 genes.
21) Cyclin D1, the product of CCND1 gene, is an important regulator of G1 to S phase progression in many different cell types.
8] The same study also noted that sinonasal melanomas carried an overexpression of CCND1 protein (65.
The CCND1 G870A gene polymorphism and brain tumor risk: a meta-analysis.
TABLA III PATRON DE LATENCIA DEL VIRUS EPSTEIN BARR Y NEOPLASIAS ASOCIADAS Latencia Genes virales Neoplasias asociadas expresados I EBNA-1 Linfoma de Burkit EBERs BARF II EBNA-1 Linfoma de Hodgkin EBERs Cancer nasofaringeo LMP-1 Linfoma periferico LMP-2 T/NK BARF III Todos EBNAs Linfomas asociados a EBERs SIDA LMP-1 Desordenes LMP-2 linfoproliferativos BARF Postransplantes TABLA IV GENES CANDIDATOS Y LINFOMAS FAMILIARES Via Genes Ciclo celular/ AICDA, BAX, BCL2,BCL2A1,BCL2L1,BCL2L2, BCL2L10, Apoptosis BCL2L11(BIM), BCL6, BCL7A, BCL7C, BCL10, CASP1, CASP14, CASP4, CASP5, CASP6, CASP7, CASP8AP2, CASP9, CCND1, LMO2, MYC, PIM1, RIPK1, RIPK2, TP53, TP53I.
Detection of CCND1 Amplification Using Laser Capture Microdissection Coupled with Real-time Polymerase Chain Reaction in Human Esophageal Squamous Cell Carcinoma.