CCN proteins

CCN proteins

A family of six cellular signalling regulator proteins with a wide range of functions. They are concerned in cell proliferation and differentiation, wound healing, OSTEOGENESIS, CHRONDROGENESIS and ANGIOGENESIS.
References in periodicals archive ?
All CCN proteins have a modular structure, which consists of four conserved cysteine rich-domains, with sequence homology to the insulin-like growth factor-binding proteins (IGFBP), the von Willebrand factor C (VWC) domain, Thrombospondin type 1 repeat (TSR), and a C-terminal domain with a cysteine-knot motif.
Lau, "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets," Nature Reviews Drug Discovery, vol.
Some CCN proteins have been demonstrated to possess growth factor-like activity and to regulate cell growth and tissue formation.
Several lines of evidence have demonstrated the participation of CCN proteins in inflammation.
CCN Proteins: A New Family of Cell Growth and Differentiation Regulators