In vitro studies revealed that IL-6 transsignaling increases chemokine activation of CXCL5, CXCL6, and CCL8
Also, studies using the Ty21a vaccine strain in a bladder cancer murine model led to tumor regression by [CD8.sup.+] T lymphocyte activation and the expression of chemokines such as CXCL5, CXCL2, CCL8
, and CCL5 .
miRNA Target Partial target genes numbers miR-2070-3p 1352 SH3D21, BCL7C, ACTR3B, EPC1 miR-222 624 RGS6, HMG20A, RBM15, NFE2 miR-502-3p 462 CRTC1, FGD1, CCL8
, STARD8 miR-6238 391 Mcph1, PDZK1 miR-7446-3p 414 KLF13, SIAH2, TUB miR-7475-5p 517 LDB1, DVL3, PEG3, LRP1, LATS2, EFHD2 miR-125a-5p 2246 ESRRa, SENP2, BCL2L12, SREBP-1, ABCA2, NNMT miR-126 2438 TNKS2, PTPRU, RGS14, NAP1L5 miR-378e 1044 IGF1R, CACNB2, RASIP1, API5, SCD5, SLC25A29 miR-7930-3p 1793 CABIN1, PCDHA2, PLXNA4
Wood dusts activated alveolar macrophages and secreted a variety of cytokines and chemokines (MIP2, TNF[alpha], TGF[beta], IL1b, CCL2, CCL3, CCL4, CCL8
, CCL11, CCL12, CCL17, CCL20, CXCL2/3, CXCL5) involved in the development and maintenance of inflammatory response [33-36].
ACKR2 binds most inflammatory CC-chemokines (CCL2, CCL5, CCL3, CCL4, CCL7, CCL8
, CCL11, CCL13, CCL17, CCL22, CCL23, and CCL24) leading to their degradation, thereby reducing local levels of inflammatory chemokines.
tuberculosis, tales como CCL8
(MCP-2), CCL7 (MCP-3), XCL1 (linfotactina) y XCL2.
Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8
, IKK, and STAT3.
Quantitative RT-PCR analyses of livers using a Mouse Inflammatory Cytokines and Receptors PCR Array (Qiagen) revealed seven genes that were significantly downregulated in [LDLR.sup.-/-]; [macLRP1.sup.-/-] mice: Ccl3, Ccl4, Ccl8
, Ccr1, Ccr2, Cxcl9, and Tnf (Figure 2(a)).
In a similar manner, SF-derived exosomes induced the release of several chemokines (CCL8
, CCL15, CCL20, and CXCL1), while downregulating the production of others (CCL7 in particular; Figures 4(a) and 4(c)).
Gene specific human Taqman[R] primers MMP1 (Hs00899659_m1), MMP13 (Hs00233992_ml), CCL2 (Hs00234140_m1) CCL8
(Hs04187715_m1), CXCL6 (Hs00605742_m1), C3 (Hs00163811_ml), CH25H (Hs02379634_s1), and LBP (Hs01084621_ml) (Applied Biosystems) were used for gene expression analysis.
Indeed, the genes encoding for CCL2, CCL8
, CCL7, RANTES, CCL3, and CCL11 chemokines, as well as those encoding for CCR1, CCR2, CCR3, and CCR5, were found upregulated in the adipose tissue of morbidly obese compared with lean subjects .
The positive self-feedback loop of CCL8
secretion recruits further neutrophils to the infarct for the phagocytosis of necrotic, autophagic, or apoptosed cardiac tissue .