CCL8


Also found in: Wikipedia.

CCL8

A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 2 (MCP-2), a secreted chemokine that is chemotactic for monocytes, lymphocytes, basophils and eosinophils. MCP-2/CCL8 is structurally related to the CXC subfamily of cytokines, and characterised by two cysteines separated by a single amino acid. MCP-2/CCL8 inhibits the chemotactic effect of CCL7, as well as CCL2, CCL5 and CCL8; it may play a role in neoplasia and inflammatory host responses.
References in periodicals archive ?
In vitro studies revealed that IL-6 transsignaling increases chemokine activation of CXCL5, CXCL6, and CCL8 [16].
Also, studies using the Ty21a vaccine strain in a bladder cancer murine model led to tumor regression by [CD8.sup.+] T lymphocyte activation and the expression of chemokines such as CXCL5, CXCL2, CCL8, and CCL5 [126].
miRNA Target Partial target genes numbers miR-2070-3p 1352 SH3D21, BCL7C, ACTR3B, EPC1 miR-222 624 RGS6, HMG20A, RBM15, NFE2 miR-502-3p 462 CRTC1, FGD1, CCL8, STARD8 miR-6238 391 Mcph1, PDZK1 miR-7446-3p 414 KLF13, SIAH2, TUB miR-7475-5p 517 LDB1, DVL3, PEG3, LRP1, LATS2, EFHD2 miR-125a-5p 2246 ESRRa, SENP2, BCL2L12, SREBP-1, ABCA2, NNMT miR-126 2438 TNKS2, PTPRU, RGS14, NAP1L5 miR-378e 1044 IGF1R, CACNB2, RASIP1, API5, SCD5, SLC25A29 miR-7930-3p 1793 CABIN1, PCDHA2, PLXNA4
Wood dusts activated alveolar macrophages and secreted a variety of cytokines and chemokines (MIP2, TNF[alpha], TGF[beta], IL1b, CCL2, CCL3, CCL4, CCL8, CCL11, CCL12, CCL17, CCL20, CXCL2/3, CXCL5) involved in the development and maintenance of inflammatory response [33-36].
ACKR2 binds most inflammatory CC-chemokines (CCL2, CCL5, CCL3, CCL4, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, and CCL24) leading to their degradation, thereby reducing local levels of inflammatory chemokines.
tuberculosis, tales como CCL8 (MCP-2), CCL7 (MCP-3), XCL1 (linfotactina) y XCL2.
Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3.
Quantitative RT-PCR analyses of livers using a Mouse Inflammatory Cytokines and Receptors PCR Array (Qiagen) revealed seven genes that were significantly downregulated in [LDLR.sup.-/-]; [macLRP1.sup.-/-] mice: Ccl3, Ccl4, Ccl8, Ccr1, Ccr2, Cxcl9, and Tnf (Figure 2(a)).
In a similar manner, SF-derived exosomes induced the release of several chemokines (CCL8, CCL15, CCL20, and CXCL1), while downregulating the production of others (CCL7 in particular; Figures 4(a) and 4(c)).
Gene specific human Taqman[R] primers MMP1 (Hs00899659_m1), MMP13 (Hs00233992_ml), CCL2 (Hs00234140_m1) CCL8 (Hs04187715_m1), CXCL6 (Hs00605742_m1), C3 (Hs00163811_ml), CH25H (Hs02379634_s1), and LBP (Hs01084621_ml) (Applied Biosystems) were used for gene expression analysis.
Indeed, the genes encoding for CCL2, CCL8, CCL7, RANTES, CCL3, and CCL11 chemokines, as well as those encoding for CCR1, CCR2, CCR3, and CCR5, were found upregulated in the adipose tissue of morbidly obese compared with lean subjects [62].
The positive self-feedback loop of CCL8 secretion recruits further neutrophils to the infarct for the phagocytosis of necrotic, autophagic, or apoptosed cardiac tissue [51].