CCL4


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Related to CCL4: N2O3

CCL4

A chemokine encoded by CCL4 (formerly LAG1, SCYA4), located on chromosome 17q21-q23, which precipitates local inflammatory response characterised by infiltration of neutrophils. It is expressed after cell activation by mitogens (phytohemagglutinin, bacterial endotoxins or Staphylococcus aureus) and IL2, and inhibited by glucocorticoids, TGF-beta and cyclosporin A.

Normal expression
T-cells, B-cells, monocytes.

Abnormal expression
Various tumour cell lines.
References in periodicals archive ?
In this study, the chemokine genes CXCL9, CXCL10, and CCL4 might be suppressed due to severely toxic levels of DON and ZEN.
Groups n Grades 0 1 2 Control 5 5 (100%) 0 (0%) 0 (0%) CCl4 + FiO2 (0.21) 10 0 (0%) 2 (20%) 5 (50%) CCl4 + FiO2 (0.07) 10 0 (0%) 0 (0%) 4 (40%) CCl4 + FiO2 (0.07) + 10 0 (0%) 7 (70%) 3 (30%) RSG (10 mg/kg) Groups Grades 3 4 Control 0 (0%) 0 (0%) CCl4 + FiO2 (0.21) 2 (20%) 1 (10%) (a) CCl4 + FiO2 (0.07) 4 (40%) 2 (20%) (a,b) CCl4 + FiO2 (0.07) + 0 (0%) 0 (0%) (a,b,c) RSG (10 mg/kg) (a) P < 0.01 as compared with control group.
Effects of kefir on liver weights and total body weights of mice treated with carbon tetrachloride (C[Cl.sub.4]) at the end of study (4 weeks) Treatment Groups Liver weight /100g body weight Control 1.1070 (n= 10) [+ or -] 0.04842 Kefir 1.1190 (n=10) [+ or -] 0.04656 CCl4 1.9900 (n= 5) [+ or -] 0.13565 (a,b) Combination 1.3900 (n= 5) [+ or -] 0.08741 (a,b,c) Total 1.3103 (n=30) [+ or -] 0.06545 Treatment Groups Body weight (% of initials) Control 27.2000 (n= 10) [+ or -] 0.48419 Kefir 27.3100(n=10) [+ or -] 0.58356 CCl4 22.3000 (n= 5) [+ or -] 0.96954 (a,b) Combination 24.4000 (n= 5) [+ or -] 0.87178 (a,b,c) Total 25.9533 (n=30) [+ or -] 0.47766 Data are presented as mean [+ or -] standard error of 10 animals/group.
In group 2 cytokines, similar changes of serum levels of cytokines PDGF-BB and CCL4 from the acute phase to the convalescent phase were observed in all the patients (K > 0.4).
Under sterile conditions, 2 mL 20% CCl4 ethanol solution was added to 48 mL serum free DMEM high glucose culture medium to formulate into 50 mL intervention culture medium with a concentration of 80 mmol/L CCl4, which was stored at 4C for later use.
africana Seed Methanolic Extract on Levels of Hemoglobin and PCV after Chronic and Acute Oxidative Stress In the chronic liver injury model the CCl4 control group showed lower percentage level of PCV and haemoglobinconcentration which was significantly (p less than 0.05) different from the untreated control group.
In which the dissolved oil sample (CCl4 used as solvent) was mixed with 25ml of Wijis (0.1mol/L) solution and reacted with freshly prepared (10%) potassium iodide solution.
In order to better understand the early events on the host-parasite interactions, in this paper, we evaluated the production of proinflammatory (IFN-[gamma], IL-12p70, CCL3, CCL4, CCL5, CXCL10) and of anti-inflammatory (IL-10, IL-13) cytokines, chemokines and chemokine receptors taking advantage of the in vitro priming system using peripheral blood mononuclear cells (PBMCs) from healthy individuals stimulated by live promastigotes of L.
Liver injury was induced in 70 male rats via subcutaneous injections of CCl4 twice a week over three months.
(9) observed upregulation of mRNA in CD34-derived DCs for IL1[beta], IL6, IL8, CCL2, CCL3, CCL4, and CCL3L1 by sensitizers.