Following the encouraging results reported by our laboratory and others using CCL28 to enhance HIVspecific IgA responses in the mucosal tract, we performed similar experiments in nonhuman primates.
For example, it is known that colonization of the intestines by commensal microbes promotes increased CCL28 secretion by intestinal epithelial cells .
Chemokine molecular adjuvants, particularly CCL28, have proven especially useful for generating humoral anti-HIV immunity at mucosal sites, leading to protection from challenge in SIV models.
Kagnoff, "Regulated production of the chemokine CCL28 in human colon epithelium," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.
Oldham et al., "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)," Journal of Biological Chemistry, vol.
Butcher, "A common mucosal chemokine (mucosae-associated epithelial chemokine/ CCL28) selectively attracts IgA plasmablasts," The Journal of Immunology, vol.
Butcher, "CCL28 controls immunoglobulin (Ig) A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate," Journal of Experimental Medicine, vol.
Lefevre et al., "Molecular cloning and functional characterization of porcine CCL28: possible involvement in homing of IgA antibody secreting cells into the mammary gland," Molecular Immunology, vol.
Quiding-Jarbrink, "Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC)," European Journal of Immunology, vol.
Nagle et al., "Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo," Gene Therapy, vol.
Tong et al., "CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue," The Journal of Immunology, vol.