CCL26


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CCL26

A gene on chromosome 7q11.23 that encodes eotaxin-3, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL26 binds CCR3 and is chemotactic for eosinophils and basophils.
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Chemokines whose concentrations were measured in the present study included CXCL8 (IL-8), CXCL9 (monokine induced by gamma interferon), CXCL10 (interferon-gamma-induced protein 10 [IP-10]), CXCL11 (interferon-inducible T-cell alpha chemoattractant), CCL4 (macrophage inflammatory protein 1[sz] [MIP-1[sz]]), CCL11 (eotaxin-1), CCL26 (eotaxin-3), CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), CCL2 (monocyte chemoattractant protein 1 [MCP-1]), and CCL13 (MCP-4).
Meso scale discovery (MSD) system (MSD, Rockville, MD, USA)[sup][12] was used to measure the concentrations of proinflammatory cytokines and chemokines for IL-1[sz], IL-6, IL-17, IL-18, TNF-a, CXCL8, CXCL10, CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 using a commercial kit (K15054G-2).
Concentrations of CC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 in bronchoalveolar lavage fluid
Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells
genes de quimiocinas CCL5/RANTES, CCL11, CCL24, CCL26, filagrina e outros) e (d) associados a funcao pulmonar e remodelamento bronquico (ADAM-33, DPP-10 e HLA-G, dentre outros).
The pathogenesis of asthma/Patogenia da asma
A role for eotaxin-3 (CCl26) in the pathogenesis of EoE has been well documented.21 Quantitative microarray analyses have shown increased expression of interleukin-15 (IL-15) messenger RNA in the esophagus of patients with EoE.
Frequency of Eosinophilic Esophagitis in patients undergoing upper GI Endoscopy
In addition, coexpression of IL-27 with CCL26 mRNA, which is prototypical of aTh2/IL-13 signature, was associated with severe asthma [96].
Dual Roles of IL-27 in Cancer Biology and Immunotherapy
Second, superantigens may induce the release of effector cytokines such as IL-4, IFN-[gamma], or IL-31 which in turn may upregulate the expression of chemokines such as CCL1, CCL11, CCL17, CCL18, CCL26, CXCL9, or CXCL10.
Role of macrophages in the pathogenesis of atopic dermatitis

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