CCL25


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CCL25

A gene on chromosome 19p13.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL25 binds CCR9; it is chemotactic for dendritic cells, thymocytes and activated macrophages, but not lymphocytes and neutrophils.
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Women had about 20% less CCL25 and CCL26 than men, and 32% less CxCL1 (fracktalkine).
29) The [alpha]4[beta]7 specifically binds MAdCAM-1, and CCR9 is the receptor for the chemokine CCL25 secreted by small intestinal venules.
Benzerdurum T hucrelerinde kemokin reseptoru CCR9 ekspresyonunun artmasi ve bu kemokinin ince barsak epitelyal hucreleri tarafindan uretilen CCL25 kemokinine afinitesi ile aciklanmaktadir.