CM-101, is a fully humanised monoclonal antibody targeting the chemokine CCL24
that is in clinical development for the treatment of patients with liver fibrotic diseases such as NASH and Primary Sclerosing Cholangitis.
GM-CSF is basically a hematopoietic and myelopoietic growth factor (17,18) which also promotes production of pro-inflammatory cytokines such as 'TNF-[alpha], IL-6, IL-12p70, IL-23 and IL-1[beta] as well as chemokines like CCL22, CCL24
, CCL5 and CCL1 which promote leukocyte recruitment' (17).
The current study reports on the gene expression and molecular characteristics of three members of the CC family of chemokines: 1) dual chemokine ligand CCL17; 2) homeostatic chemokines ligand CCL21; and 3) CCL24
in response to bacterial challenge in large yellow croaker (Larimichthys crocea).
), a member of the CC chemokine family, is a potent chemoattractant for eosinophils, basophils, and lymphocytes, distributed in a variety of tissues, including human brain .
IGFBP-1: Insulin-like growth factor-binding protein 1 IGFBP-2: Insulin-like growth factor-binding protein 2 BDNF: Brain-derived neurotrophic factor L-Selectin: CD62L E-Selectin: CD62E ICAM-1: Intercellular adhesion molecule 1 PECAM: Platelet endothelial cell adhesion molecule VCAM-1: Vascular cell adhesion protein 1 MIP-1d: Chemokine (C-C motif) ligand 15 (CCL15) MIP-3b: Macrophage inflammatory protein-3 (CCL19) Eotaxin-1: C-C motif chemokine 11 (CCL11) Eotaxin-2: Chemokine (C-C motif) ligand 24 (CCL24
) BLC: B lymphocyte chemoattractant.
These 27 SNPs in 12 chemokine genes, included 4 SNPs (rs1024610, rs1024611, rs13900, and rs4586) of CCL2 [21, 22], 5 SNPs (rs4251719, rs2306630, rs2107538, rs9355610, and rs2280788) of CCL5 [12, 23, 24], 1 SNP (rs854680) of CCL16 , 2 SNPs (rs223828 and rs223895) of CCL17 [26-28], 3 SNPs (rs951005, rs2492358, and rs2812378) of CCL21 [29-31], 1 SNP (rs4359426) of CCL22 , 2 SNPs (rs2302004 and rs2302005) of CCL24
, 3 SNPs (rs2227306, rs2227543, and rs4694178) of CXCL8 , 2 SNPs (rs2276886 and rs2869460) of CXCL9 [14, 35], 1 SNP (rs2869462) of CXCL10 , 2 SNPs (rs1801157 and rs2839693) of CXCL12 [13, 15], and 1 SNP (rs2277680) of CXCL16 .
 A higher transcription of both Chemokine Ligands (CCL24
) as well as Chemokine Receptors (CCR6) have been reported recently in major depressive disorders.
ACKR2 binds most inflammatory CC-chemokines (CCL2, CCL5, CCL3, CCL4, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, and CCL24
) leading to their degradation, thereby reducing local levels of inflammatory chemokines.
genes de quimiocinas CCL5/RANTES, CCL11, CCL24
, CCL26, filagrina e outros) e (d) associados a funcao pulmonar e remodelamento bronquico (ADAM-33, DPP-10 e HLA-G, dentre outros).
The company's lead investigational drug candidate, CM-101, is targeting the chemokine CCL24
, an important driver of fibrotic processes.
T cells and inflammatory tracheal epithelial cells released more eotaxins (CCL11 and CCL24
) to induce mature eosinophil migration into the airways.