CCL23


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CCL23

A gene on chromosome 17q12 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL23 binds CCR1; it is chemotactic for resting T lymphocytes and monocytes, has some effect on neutrophils and no effect on activated T lymphocytes. CCL23 is a strong suppressor of colony formation by multipotential haematopoietic stem cells.
References in periodicals archive ?
In addition, cytokine-cytokine receptor interaction signaling pathways were predicted to have strong relationships with the target genes, such as CCL23 ( ENST00000591423 ) , CCR10 ( NM_016602 ), and TNFRSF6B (NM_003823) .
Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells.
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony stimulating factor.