These biomarkers were: MMP-3, MMP-10, MMP-12, MMP-13, IL-6, IL-10, CCL20
, A2M, ICAM-1 and VEGF-C.
C-C motif chemokine ligand 20 (CCL20
)'C-C motif chemokine receptor 6 (CCR6) is known to be effective in the progression of NSCLC with the pro-inflammatory and proliferative effects (13).
Among differentially expressed genes, IL1B, IL17F, IL6R, CXCL2, CCL20
and CCL25 were selected based on their immunological functions and CD8B and CD81 may contribute to variations of blood T lymphocyte subsets.
(64) and CSF CXCL1, CXCL8, CXCL10, CXCL13, CCL20
, CCL22, NfL, NfH, GFAP, chitinase-3-like-1 MMP-9, osteopontin levels in RIS and RRMS cases Petzold (65) Relationship between CSF NfH values and clinical EDSS Petzold et al.
In order to validate the expression profiles observed in the gene expression profile, immunohistochemistry was pursued for chemokine (C-C motif) ligand 20 (CCL20
), CCR6, mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), and protocadherin gamma A3 (PCDHGA3), A8 (PCDHGA8), and B4 (PCDHGB4).
For example, E2 downregulated C-C motif chemokine ligand (CCL) 16 (CCL16, GeneID 6360) and PPT downregulated CCL20
(GeneID 6364), whereas E2 upregulated CCL26 (GeneID 10344), C-C motif chemokine receptor 7 (CCR7, GeneID 1236), and C-X-C motif chemokine ligand 16 (CXCL16, GeneID 58191).
The activation of Th17 cells results in a large amount of inflammatory cytokine production, such as IL17A, IL17F, IL21, IL22, and CCL20
TAMs also orchestrate the recruitment of T regulatory cells, by secreting CCL20
[106, 107] andCCL22 , and their activation through a bidirectional interaction by the release of IL-10 and TGF-[beta] [107, 109-111].
Shen et al., "ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20
induction," European Journal of Cancer, vol.
Among them, we found the principal components of major regulatory clusters, involving inflammatory responses (IFNy, IL6, several members of the interleukin 1 pathway, including ILIA, IL1B, IL1RN, and the TNF pathway members TNF, TNFAIP6, TNFSF15, TNFRSF9), angiogenesis (CXCL10, PTGS2), immune regulation (CD80, CD274, CSF3, IL23R), leukocyte chemotaxis (CCL2, CCL3, CCL4, CCL20
, CCL23, CCL3L3, CXCL1, CXCL2, CXCL5, CXCL9), transcriptional regulation (EGR1, GATA6, HEY1), proliferation (CDKN2B, FGFR1), adhesion (ITGB8), extracellular matrix remodeling (ADAMTS4), cell-cell communication (GJB2), cell signaling (EDNRB, IRS1, RIN2), ion transmembrane transport (KCNJ2, CLIC4), and response to oxidative stress (SOD2).
Yang et al., "The novel long noncoding RNA U50535 promotes colorectal cancer growth and metastasis by regulating CCL20
," Cell Death & Disease, vol.
(23) Also, Choi and his colleagues demonstrated that DA-9601, a standardized aqueous extract of Artemisia Asiatica, blocks TNF-[alpha]-induced IL-8 and CCL20
production by inhibiting p38 kinase and NF[kappa]B pathways in human gastric epithelial cells.