CCL20


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CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.
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23) Also, Choi and his colleagues demonstrated that DA-9601, a standardized aqueous extract of Artemisia Asiatica, blocks TNF-[alpha]-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF[kappa]B pathways in human gastric epithelial cells.
Al mismo tiempo, se ha observado que ciertas adipocitocinas dirigen la expresion y funcion de la compleja red de quimiocinas como MCP-1y CCL20, que regulan la acumulacion de celulas inflamatorias en el TAV y de esta forma, fomentan el desarrollo de la inflamacion local (30, 78).
In view of the frequent rheumatic involvement in IBD, it is worth knowing that CCR6 and its receptor CCL20 are crucial in the development of Th17-dependent joint pathology [58].
Indeed recently, we have shown that GE (without LC), topically exposed to an allergen or an irritant, secrete negligible amounts of key cytokines and chemokines (IL-18, CCL2, CCL20, CXCL12) involved in LC migration compared to skin, whereas the general inflammatory cytokine CXCL8 was secreted at similar levels by SE and GE (Kosten et al.
2014) CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition.
For instance, it has been shown that cigarette smoke can induce the production of cytokines that play a role in recruitment, differentiation, and activation of Langerhans cells and dendritic cells, including TNF[alpha], granulocyte macrophage-colony stimulating factor (GM-CSF), TGF[beta], and CCL20.
Higher circulating levels of chemokine CCL20 in patients with multiple sclerosis: evaluation of the influences of chemokine gene polymorphism, gender, treatment and disease pattern.
In contrast, 18 cytokines genes (BMPER, CCL19, CCL20, CCL4, CXCL14, IFNB, IL-12A, IL-17B, IL-17D, IL-17F, IL-19, IL-22, IL-26, IL-7, LIF, NLRC3, TGFA, and VEGFA) and 14 receptor genes (CXCR3, IFITM5, IL-13RA1, IL-17RC, IL-1RAPL2, IL-22RA1, IL-22RA2, ILDR1, LILRA5, LTBP2, PDGFD, PDGFRL, TNFRSF14, and TNFRSF6B) were markedly downregulated by 2.
2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.
DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced 1L-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells.
Este estudio nos permitio identificar niveles aumentados de transcritos para CCL19 y CCL20.