CCL2

Also found in: Wikipedia.

CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.

Mentioned in ?

References in periodicals archive ?

The latter is important, as proteins previously identified as potential biomarkers for endometriosis such as the chemokines CXCL8, CCL2, and CCL5 vary during the menstrual cycle which practically limits their diagnostic value.

Preoperative Diagnosis of Endometriosis

13 Recent study found that ACKR1 polymorphism is associated with serum concentration of CCL2 belonging to the CC family.

Atypical Chemokine Receptor 1 polymorphism cannot be used as an indicator of liver fibrosis progression in Hepatitis C virus positive patients

10] More interestingly, some studies showed the SNP (single nucleotide polymorphism) subtypes, rs4795893, rs1024611, rs4586 and rs2857657, of CCL2, the coding gene of MCP-1, were associated with treatment resistance of risperidone in the Han Chinese population.

Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia

Recent studies have found that ACKR1 polymorphism is associated with serum levels of CCL2 belonging to the CC family (29,30).

Atypical Chemokine Receptor 1 Polymorphism can not Affect Susceptibility to Hepatitis C Virus

12) Thus, CCL2 produced by pancreatic acinar cells emerged as the key pathogenic chemokine in the development of acute pancreatitis induced by simultaneous activation of NOD1 and CCKR.

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Serum CCL2 and serum TNF-a-two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal carcinoma.

Retrospective analytical study of association between ABO blood group and malignancy

Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions.

Components of the alternative complement pathway in patients with psoriasis

20) have investigated the effects of IVMP treatment for 5 days on IL-12 and IL-10 levels and CCL2 chemokine expressions.

Efficacy of different durations of intravenous methylprednisolone treatment in relapses of multiple sclerosis

BMP15 prevents cumulus cell apoptosis through CCL2 and FBN1 in porcine ovaries.

Short term organ culture of mouse ovary in the medium supplemented with bone morphogenetic protein 15 and follicle stimulating hormone: a morphological, hormonal and molecular study

2015) 2/3 HTP assays Two key signaling available for pathways that primary angiogenic interact: VEGFRand pathway TGF- mediated molecular signaling targets: pathways leading VCAM, CXCL9 to the creation of and, THBD, the tumor microenvironment CCL2, ICAM, and uPAR, col111, angiogenesis CXL10, MMP1, AhR (role in cell cycle regulation) miRNA target genes involved in angiogenesis (Caporali and Emanueli, 2011) Potential adaptation of Hen's egg test-chorioallantoic membrane (HET-CAM) 2 Assays available Caspase pathway, for, e.

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance.

Macrofagos del tejido adiposo, asociacion con obesidad y alteraciones metabolicas

It was found that all compounds under study inhibited proliferation of CCL2 in a dose-dependent mode in 72 h after their addition to the culture medium.

Investigation of cytotoxic effects of some novel synthesized iminothiazolidinone derivatives on HeLa cell line (CCL2)