CCL2


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CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells.
Decreases in serum concentrations of key cytokines associated with B-cell malignancies, CCL2, CCL3, and CCL4, were observed in most evaluable patients, consistent with inhibition of BTK signaling.
Relationship between Circulating Levels of IFNg, IL10, CXCL9 and CCL2 in Pulmonary and Extrapulmonary Tuberculosis is Dependent on Disease Severity.
A plethora of proinflammatory mediators, such as interleukin (IL)-1[beta], IL-6, IL-8, cyclooxygenase (COX) 2, and chemokine CC motif ligand (CCL) 2 (CCL2), as well as proteolytic enzymes like matrix metalloproteinase (MMP) 1, are involved in these immunoinflammatory processes.
2017); therefore, we examined NR1I3, Flavin Containing Monooxygenase 5 (Fmo5), and C-C Motif Chemokine Ligand 2 (Ccl2) (Kiyosawa et al.
Data-mining showed that these peptides can be divided into further groups according to the type of processes they take part in: 1) catabolism: growth hormone 1 (GH1) and leptin (LEP); 2) neuron homeostasis: BDNF; 3) immune response: chemokine (C-C motif) ligand 2 (CCL2) and tumor necrosis factor (TNF); and 4) behavioral reactions: corticotropin-release hormone (CRH).
Advanced age of renal transplant recipients correlates with increased plasma concentrations of interleukin-6, chemokine ligand 2 (CCL2), and matrix metalloproteinase 2, and urine concentrations of CCL2 and tissue inhibitor of metalloproteinase 1.
Injury induced expression of the chemokine CCL2 in the DRG and SN attracts the macrophages to those sites.
The latter is important, as proteins previously identified as potential biomarkers for endometriosis such as the chemokines CXCL8, CCL2, and CCL5 vary during the menstrual cycle which practically limits their diagnostic value.[4] It would have been interesting and helpful if the authors combined CEC and CA125 as a panel of biomarkers to assess whether the combination had increased diagnostic value compared to CEC alone.
To test whether the cytokines identified in the conditioned media mediated the bladder cancer cell migration, media containing the following selected recombinant factors: interleukin-8 (IL8) at 10ng/ml, chemokine (C-X-C motif) ligand 1 (CXCL1) at 10 ng/ml, plasminogen activator inhibitor 1 (PAI1) at 40 nM, interleukin6 (IL6) at 5ng/ml, fractalkine (CX3CL1) at 10ng/ml, and monocyte chemoattractant protein 1 (CCL2) at 1 ng/ml, was placed in the lower well of a Transwell system.
In particular, this is illustrated by significant differences in genes related to neoangiogenesis and tissue remodeling (such as Ccl2, Hif1[alpha], Fgf7, and Igf) (Figures 1(a) and 1(b)).