CCL18

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL18 is chemotactic for naïve T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. It attracts naïve T cells toward dendritic cells and activated macrophages in lymph nodes, and may play a role in humoral and cell-mediated immune responses.

References in periodicals archive ?

However, there was no significant difference in the serum levels of CCL18 and SP-A between patients with IPF and patients with BP.

Only KL-6 showed a high discriminatory ability whereas SP-A and CCL18 were poor indicators for discriminating IPF from BP (Table S1(a) and Figure S2(a)).

Survival was significantly different between higher and lower levels of MMP-7, CCL18, and KL-6 (Figure S3).

In the present study, we directly compared the diagnostic and prognostic value of five serum biomarkers--MMP-7, CCL18, KL-6, SP-A, and SP-D--in patients with IPF and control subjects.

Our study also demonstrated that serum levels of CCL18 had moderate discriminatory ability for differentiating IPF patients from the HC; however, CCL18 was found to be a poor indicator for distinguishing IPF from BP.

Additionally, serum levels of CCL18 were shown to be elevated in patients with HP when compared with patients with IPF and NSIP [32].

Atamas, "Complex regulation of pulmonary inflammation and fibrosis by CCL18," The American Journal of Pathology, vol.

Comparative study of circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as disease markers of idiopathic pulmonary fibrosis

On the other hand, production of anti-inflammatory CCL18 was decreased both in atherosclerosis and in cancer patients [22].

The analysis of TNF[alpha] and CCL18 production by stimulated macrophages revealed dramatic individual differences between the analyzed subjects that may reflect the individuals' predisposition to immunopathology.

For instance, M1 macrophages release TNF[alpha], IL-1[beta], IL-6, IL-12, and other proinflammatory cytokines, whereas M2a macrophages produce CCL18, TGF-[beta], collagen, and other extracellular matrix components.

Secretion of TNF[alpha] and CCL18 was measured by ELISA.

Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy