CCL18

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL18 is chemotactic for naïve T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. It attracts naïve T cells toward dendritic cells and activated macrophages in lymph nodes, and may play a role in humoral and cell-mediated immune responses.

References in periodicals archive ?

MMP-7, CCL18, SP-A, and SP-D were measured by commercially available enzyme-linked immunosorbent assay (ELISA) kits (Human Total MMP-7 Quantikine ELISA Kit, R&D Systems, MN; Human CCL18/PARC Quantikine ELISA Kit, R&D Systems, MN; SP-A Test Kokusai-F Kit, Sysmex, Japan; and SPD EIA Kit Yamasa, Yamasa, Japan).

Comparative study of circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as disease markers of idiopathic pulmonary fibrosis

Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes.

Modern concepts on the role of inflammation in pulmonary fibrosis

Although we did not detect any SNP associated with either oxidative DNA damage or IUGR, in univariate analysis we found four genes (MBL2, CCL7, CCL11, and CCL18) modifying the incidence of LBW.

Genetic, biochemical, and environmental factors associated with pregnancy outcomes in newborns from the Czech Republic

DCM did not induce spontaneous expression of M1 (iNOS, CD86, and TNF-[alpha]; Figures 4(d), 4(e), and 4(f)) or M2 markers {arginase 1 (Arg1) and CC motif ligand 18 (CCL18); Figures 4(g) and 4(h)} in NR8383 cells.

Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells

They express IL-1 receptor antagonist (IL-1ra) and secrete CCL18, transforming growth factor [beta] (TGF-[beta]), and remodelling enzymes.

Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy

Classification Number Cytokines Panel 1 6 TNF-RII, IL19, CCL5/RANTES, MIF, MPO, Galectin-3bp Panel 2 1 IL-23 IFN/gamma, TNF/alpha, TNF/RI, GM/CSF, Panel 3 37 IL/1 beta, IL/1ra, IL1/RII, IL2, IL2 R alpha, IL4, IL5, IL6, IL6R alpha, CXCL8/ IL8, IL10, IL/15, IL17A, IL22, CCL2, CCL4, CCL7, CCL11, CCL13, CCL18, CCL22, CCL27, CXCL1/GRO alpha, CXCL4, CXCL10, CXCL12/SDF-1 alpha, CXCL13, CD14, CD27, CD30, CD40, NCAM-1/CD56, B7-H1/PD-L1/ CD274 Table 2: The outcomes of monkeys infected with M.

Dynamics of Immune Responses during Experimental Mycobacterium kansasii Infection of Cynomolgus Monkeys (Macaca fascicularis)

Laplante et al., "CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling," Molecular Cancer, vol.

The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

The chemokine CCL18, which reflects the amount of macrophage activation, and chitotriosidase are both indicative of disease severity and the response of Gaucher patients to ERT.

Immunochemistry of lysosomal storage disorders

A wide variety of proinflammatory mediators in COPD (like CXCL8, IL-6, and CCL18) overlap with CF-related mediators [74, 81].

The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology

Although there is a high variation among patients, increased levels of IL-1[alpha], IL-1[beta], IL-1Ra, sIL-2R, IL-6, IL-8, IL-10, IL-18, TNF-[alpha], TGF-[beta], M-CSF, MIP-1, and CCL18 have been reported in sera [39-41].

Pathogenesis of bone alterations in Gaucher disease: the role of immune system

Pfeiffer, "CCL18 is expressed in patients with bullous pemphigoid and paralells disease course," The British Journal of Dermatology, vol.

Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis

Recently, Chen and colleagues [48] linked TAM-produced CCL18 with cancer cell invasiveness and identified PITPNM3 (a membrane-associated phosphatidylinositol transfer protein) as its receptor.

The role of chemokines in breast cancer pathology and its possible use as therapeutic targets