CCL17


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CCL17

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL17 binds CCR4 and CCR8, is chemotactic for T cells (but not monocytes or granulocytes), and plays key roles in T-cell development in thymus and in the trafficking and activation of mature T cells.
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The current study reports on the gene expression and molecular characteristics of three members of the CC family of chemokines: 1) dual chemokine ligand CCL17; 2) homeostatic chemokines ligand CCL21; and 3) CCL24 in response to bacterial challenge in large yellow croaker (Larimichthys crocea).
CCL17 Induces Trophoblast Migration and Invasion by Regulating Matrix Metalloproteinase and Integrin Expression in Human First-Trimester Placenta.
Based on the functional categorization of chemokines as described by Zlotnik and Yoshie [30], the elevated chemokines in TS-CONTROL compared to TS-COPD can be classified as follows: Inflammatory (CCL1, 7, and 15; CXCL2 and 9), homeostatic (CCL19, CCL25), and dual function (CCL17).
Moreover, the migration of [CD4.sup.+] [CD25.sup.+] T cells to periodontitis that affected gingival tissues seemed to be dependent on CCL17 and CCL22 expression by the local inflammatory infiltrate, which recruits Treg expressing CCR4 or CCR8 [37, 38].
Hasegawa et al., "Elevated serum thymus and activation-regulated chemokine (TARC/ CCL17) relates to reactivation of human herpesvirus 6 in drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS)," British Journal of Dermatology, vol.
Methods: Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1[sz]; tumor necrosis factor-alpha (TNF-a); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.
Skin T cells also express another chemokine receptor CCR4, whose engagement with a dermal venule-expressed chemokine, CCL17, promotes T cell migration into the skin.
These 27 SNPs in 12 chemokine genes, included 4 SNPs (rs1024610, rs1024611, rs13900, and rs4586) of CCL2 [21, 22], 5 SNPs (rs4251719, rs2306630, rs2107538, rs9355610, and rs2280788) of CCL5 [12, 23, 24], 1 SNP (rs854680) of CCL16 [25], 2 SNPs (rs223828 and rs223895) of CCL17 [26-28], 3 SNPs (rs951005, rs2492358, and rs2812378) of CCL21 [29-31], 1 SNP (rs4359426) of CCL22 [32], 2 SNPs (rs2302004 and rs2302005) of CCL24 [33], 3 SNPs (rs2227306, rs2227543, and rs4694178) of CXCL8 [34], 2 SNPs (rs2276886 and rs2869460) of CXCL9 [14, 35], 1 SNP (rs2869462) of CXCL10 [35], 2 SNPs (rs1801157 and rs2839693) of CXCL12 [13, 15], and 1 SNP (rs2277680) of CXCL16 [36].
IL-4 induced M2 macrophages expressed high concentration of IL-10, decoy receptor IL-1R, IL-1R antagonist, chemokines CCL22 and CCL17, and intracellular enzyme arginase-1.
Wood dusts activated alveolar macrophages and secreted a variety of cytokines and chemokines (MIP2, TNF[alpha], TGF[beta], IL1b, CCL2, CCL3, CCL4, CCL8, CCL11, CCL12, CCL17, CCL20, CXCL2/3, CXCL5) involved in the development and maintenance of inflammatory response [33-36].
Recruitment of T cells can be supported by macrophages-secreted CCL17 [44].