C-C motif chemokine ligand Mediating by chemotaxis 17 the infiltration of Th2 cells in inflammatory reaction Gene Symbol Time FC 1.
The current study reports on the gene expression and molecular characteristics of three members of the CC family of chemokines: 1) dual chemokine ligand CCL17
; 2) homeostatic chemokines ligand CCL21; and 3) CCL24 in response to bacterial challenge in large yellow croaker (Larimichthys crocea).
Induces Trophoblast Migration and Invasion by Regulating Matrix Metalloproteinase and Integrin Expression in Human First-Trimester Placenta.
Based on the functional categorization of chemokines as described by Zlotnik and Yoshie , the elevated chemokines in TS-CONTROL compared to TS-COPD can be classified as follows: Inflammatory (CCL1, 7, and 15; CXCL2 and 9), homeostatic (CCL19, CCL25), and dual function (CCL17
Moreover, the migration of [CD4.sup.+] [CD25.sup.+] T cells to periodontitis that affected gingival tissues seemed to be dependent on CCL17
and CCL22 expression by the local inflammatory infiltrate, which recruits Treg expressing CCR4 or CCR8 [37, 38].
Hasegawa et al., "Elevated serum thymus and activation-regulated chemokine (TARC/ CCL17
) relates to reactivation of human herpesvirus 6 in drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS)," British Journal of Dermatology, vol.
Methods: Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1[sz]; tumor necrosis factor-alpha (TNF-a); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17
, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.
Skin T cells also express another chemokine receptor CCR4, whose engagement with a dermal venule-expressed chemokine, CCL17
, promotes T cell migration into the skin.
These 27 SNPs in 12 chemokine genes, included 4 SNPs (rs1024610, rs1024611, rs13900, and rs4586) of CCL2 [21, 22], 5 SNPs (rs4251719, rs2306630, rs2107538, rs9355610, and rs2280788) of CCL5 [12, 23, 24], 1 SNP (rs854680) of CCL16 , 2 SNPs (rs223828 and rs223895) of CCL17
[26-28], 3 SNPs (rs951005, rs2492358, and rs2812378) of CCL21 [29-31], 1 SNP (rs4359426) of CCL22 , 2 SNPs (rs2302004 and rs2302005) of CCL24 , 3 SNPs (rs2227306, rs2227543, and rs4694178) of CXCL8 , 2 SNPs (rs2276886 and rs2869460) of CXCL9 [14, 35], 1 SNP (rs2869462) of CXCL10 , 2 SNPs (rs1801157 and rs2839693) of CXCL12 [13, 15], and 1 SNP (rs2277680) of CXCL16 .
IL-4 induced M2 macrophages expressed high concentration of IL-10, decoy receptor IL-1R, IL-1R antagonist, chemokines CCL22 and CCL17
, and intracellular enzyme arginase-1.
Wood dusts activated alveolar macrophages and secreted a variety of cytokines and chemokines (MIP2, TNF[alpha], TGF[beta], IL1b, CCL2, CCL3, CCL4, CCL8, CCL11, CCL12, CCL17
, CCL20, CXCL2/3, CXCL5) involved in the development and maintenance of inflammatory response [33-36].
Recruitment of T cells can be supported by macrophages-secreted CCL17