CCL17


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CCL17

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL17 binds CCR4 and CCR8, is chemotactic for T cells (but not monocytes or granulocytes), and plays key roles in T-cell development in thymus and in the trafficking and activation of mature T cells.
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Methods: Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1[sz]; tumor necrosis factor-alpha (TNF-a); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.
Skin T cells also express another chemokine receptor CCR4, whose engagement with a dermal venule-expressed chemokine, CCL17, promotes T cell migration into the skin.
IL-4 induced M2 macrophages expressed high concentration of IL-10, decoy receptor IL-1R, IL-1R antagonist, chemokines CCL22 and CCL17, and intracellular enzyme arginase-1.
Recruitment of T cells can be supported by macrophages-secreted CCL17 [44].
CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer.
However, additional studies involving stimulation of human epidermal keritonocyte cell lines with human IL-31 induced the expression of several proallergic chemokines, including TARC/ CCL17 (thymus- and activation-regulated chemokine) and MDC (macrophage-derived chemokine)/CCL22 that are important to the recruitment of inflammatory cells to the skin (Dillon et al.
Now, an international team of researchers led by Professor Christian Weber of Ludwig-Maximilians-University (LMU) Munich and Privatdozentin Alma Zernecke of WE-rzburg University has demonstrated that dendritic cells release the chemokine CCL17 as a signal molecule, which inhibits a feedback mechanism that normally limits the activity of the immune system.
Except for CCL17 and IL12B p40, all fold inductions measured with real-time PCR were significantly different from 0.
Role of chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus.
These infiltrated Tregs respond to CCL17 and CCL22 released by activated DCs, thus resulting in their accumulation in the liver with dendritic cells-rich inflammatory infiltrates.
Hayashida S, Uchi H, Moroi X Furue M: Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitis.