CCL16


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CCL16

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL16 is chemotactic for lymphocytes and monocytes, but not neutrophils. It is a potent myelosuppressor, suppressing the proliferation of myeloid stem cells. CCL16 expression is upregulated by IL-10.
References in periodicals archive ?
In our study, 26 SNPs covering 12 chemokine genes (CCL2, CCL5, CCL16, CCL17, CCL21, CCL22, CCL24, CXCL8, CXCL9, CXCL10, CXCL12, and CXCL16) were selected on the basis of earlier association studies in autoimmune diseases, including type 1 diabetes [12], pediatric Crohn's disease [14], and systemic lupus erythematosus [15].
Cappello et al., "CCL16 activates an angiogenic program in vascular endothelial cells," Blood, vol.
MCP-2 (CCL8), MCP-3 (CCL7), MPIF-1 (CCL23) and 6 Ckine (CCL21) also belongs to the same family as HCC4 (CCL16) [34].