CCL14


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CCL14

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL13 binds CCR1, CCR3 and CCR5, induces changes in intracellular calcium concentration and enzyme release in monocytes, but no chemotaxis. It enhances the proliferation of CD34 myeloid stem cells.
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Genes expressed more highly in OECs were Jagged 1 (JAG1), JAG2, placental growth factor (PGF), endothelial cell-specific molecule 1 (ESM1), neurite growth-promoting factor 2 (MDK), inhibin beta A (INHBA), growth differentiation factor-3 (GDF3), pre-B-cell colony-enhancing factor 1 (PBEF1), endothelin 1 (EDN1), interleukin 32 (IL32), heparin-binding EGF-like growth factor (HBEGF), chemokine (C-X-C motif) ligand 1 (CXCL1), chemokine (C-C motif) ligand 2 (CCL2), CCL14, CCL15, bone morphogenetic protein 2 (BMP2), BMP4, and BMP6, whereas genes expressed more highly in MSCs were wingless-type MMTV integration site family, member 5A (WNT5A), CXCL5, vascular endothelial growth factor (VEGF), CCL20, angiopoietin 1 (ANGPT1), growth differentiation factor 5 (GDF5), and WNT5B (Figure 7).
Based on gene expression profiling, we found that MSCs showed high gene expression of WNT5A, CXCL5, VEGF, CCL20, ANGPT1, GDF5, and WNT5B, whereas OECs showed high gene expression of JAG1, JAG2, PGF, ESM1, MDK, INHBA, GDF3, PBEF1, EDN1, IL32, HBEGF, CXCL1, CCL2, CCL14, CCL15, BMP2, BMP4, and BMP6.
Together with certain other chemokines (CCL4, CCL7, and CCL14), CX3CL1 is involved in the processes of implantation, trophoblast invasion into the spiral uterine arteries, placental angiogenesis, response to inflammatory and immunologic factors within the utero-placental unit, and induction of labor [15-17].
The inflammatory response-related genes (CCL14 (-4.52), LEP (-3.73) and PTGDS (-3.84)) showed decreased expression in the recurrence tumor tissues.
Salamonsen, "The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface," Biology of Reproduction, vol.
Together with some other chemokines (CCL4, CCL7, CCL14) CX3CL1 participates in the processes of implantation, trophoblast invasion into the spiral uterine arteries, placental angiogenesis, response to inflammatory and immunologic factors within the uteroplacental unit, and induction of labor [19-21].