CCL11


Also found in: Wikipedia.

CCL11

A gene on chromosome 17q21.1-q21.2 that encodes eotaxin-1, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. Eotaxin-1/CCL11 binds CCR3, is chemotactic for eosinophils—but not mononuclear cells or neutrophils—and is involved in eosinophilic type inflammatory responses (e.g., atopic dermatitis, allergic rhinitis, asthma and parasitic infections).
Mentioned in ?
References in periodicals archive ?
Seven ligands, CCL11, CCL17, CCL20, CCL22, XCL1, XCL2, and CX3CL1, were categorized as dual-function chemokines, which have both inflammatory and homeostatic functions.
Assessing serum cytokine levels such as interleukin 1 (IL-1), IL-2, IL-6, and chemobine CCL11 in schizophrenic patients demonstrates profound alterations compared to healthy matched controls (4).
Eotaxin1 (CCL11) controls both the eosinophil-mediated immune response [16] and other immune responses of Th2 cells [17].
The eotaxin family currently includes three members: eotaxin-1 (CCL11), eotaxin-2 (CCL24), and eotaxin-3 (CCL26).
Twenty-three cytokines were included: IFN-[alpha], IFN-[gamma], TNF-[alpha], IL-6, IL-8, IL-10, IL-1[beta], IL-18, IL-23, IL-33, IL-17A, IL-12, CXCL9, CXCL11, CXCL5, CCL2, CCL11, CCL17, CCL20, MIP-1[alpha], MIP-1[beta], IP-10, and RANTES.
IGFBP-1: Insulin-like growth factor-binding protein 1 IGFBP-2: Insulin-like growth factor-binding protein 2 BDNF: Brain-derived neurotrophic factor L-Selectin: CD62L E-Selectin: CD62E ICAM-1: Intercellular adhesion molecule 1 PECAM: Platelet endothelial cell adhesion molecule VCAM-1: Vascular cell adhesion protein 1 MIP-1d: Chemokine (C-C motif) ligand 15 (CCL15) MIP-3b: Macrophage inflammatory protein-3 (CCL19) Eotaxin-1: C-C motif chemokine 11 (CCL11) Eotaxin-2: Chemokine (C-C motif) ligand 24 (CCL24) BLC: B lymphocyte chemoattractant.
But researchers at Boston University say they have found a new biomarker called CCL11 that may enable the disease to be recognised while the sufferer is alive.
Department of Veterans Affairs, discovered elevated levels of a protein called CCL11 in the brains of dead football players with Chronic Traumatic Encephalopathy (CTE), but not in the brains of healthy people or people with Alzheimer's disease.
Clinical utility of circulating matrix metalloproteinase-7(MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer.
(61) He also showed that inflammatory factors in the blood that increase with age, such as CCL11 caused reduction in stem cell activity.
In addition to IL-5, IL-13 and IL-9, [O.sub.3] also caused greater increases in BAL CXCL1, IL-6, IL-2, eotaxin (CCL11), CSF3, IL-1a, IL-10, IL-12 (p40), CXCL10, LIF, RANTES, CXCL9, and CCL4 in the same cohort of [O.sub.3]-exposed isotype-treated db/db versus WT mice (Figure 2D-P).
Gounni, "Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway smooth muscle cells," Journal of Immunology, vol.