It is possible that the above-presented decreased secretory response of pancreatic acini to caerulein could be related to the changes in the CCK receptor, because the signal for the CCK1 receptor was significantly and dose-dependently reduced in the pancreatic acini obtained from adult rats injected with endotoxin in the suckling period of life (Figure 3) .
This impairment of the pancreatic exocrine secretory function could be related, at least in part, to the changes in the CCK1 receptor on pancreatic acini.
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Above pancreatostimulatory effects of luminal administration of melatonin, were completely reversed by bilateral vagotomy, capsaicin deactivation of sensory nerves or pretreatment of the rats with CCK1
receptor antagonist; tarazepide as well as serotonin antagonist; ketanserin.
Involvement of endogenous CCK and CCK1
receptors in colonic motor function.