CCL28

(redirected from CCK1)

CCL28

A gene on chromosome 5p12 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL28 binds CCR3 and CCR10, and is chemotactic for resting CD4 or CD8 T cells and eosinophils; it may play a role in the physiology of extracutaneous epithelia, including mucosal tissues.
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It is possible that the above-presented decreased secretory response of pancreatic acini to caerulein could be related to the changes in the CCK receptor, because the signal for the CCK1 receptor was significantly and dose-dependently reduced in the pancreatic acini obtained from adult rats injected with endotoxin in the suckling period of life (Figure 3) [31].
This impairment of the pancreatic exocrine secretory function could be related, at least in part, to the changes in the CCK1 receptor on pancreatic acini.
Covasa, "Intestinal nutrients elicit satiation through concomitant activation of CCK1 and 5-HT3 receptors," Physiology & Behavior, vol.
Su et al., "Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells," British Journal of Pharmacology, vol.
Above pancreatostimulatory effects of luminal administration of melatonin, were completely reversed by bilateral vagotomy, capsaicin deactivation of sensory nerves or pretreatment of the rats with CCK1 receptor antagonist; tarazepide as well as serotonin antagonist; ketanserin.
Involvement of endogenous CCK and CCK1 receptors in colonic motor function.