RUNX2

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RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
A high-resolution CCD camera (CCD1) is set for real-time monitoring the spatial evolution of control lasers.
Parameters CCD1 and CCD2 IRS Band 1-4 5-7 8 Spectral range ([micro]m) 0.43-0.90 0.75-3.90 10.5-12.5 Spatial resolution (m) 30 150 300 Amplitude width (km) 360 720 Revisit cycle (days) 2 4 Table 2: Comparison between daily air temperature and seasonal average air temperature.
The recombined object and reference beams were filtered and sent to the CCD camera (CCD1, 1392 x 1040 pixels array; pixel dimensions [DELTA]x = [DELTA]y = 4.7 [micro]m).
The product of TSC2 gene, tuberin, which consists of 1807 amino acids, is known to have seven domains including a leucine zipper region, two small coiled-coil domains (CCD1, CCD2), a small region of similarity with GTPase-activating protein (GAPD), two transcriptional activation domains (TAD1, TAD2), and a calmodulin-binding site (CaMD) in the carboxyl terminus of tuberin.
Ufier: Economics PhD Student and Instructor, Department of Economics, University of Oklahoma, 308 Cate Center Drive, Room 335 CCD1, Norman, OK 73019.
On the other hand, SnoN enhances the transcription of actin binding protein Ccd1, a positive regulator of axon growth through the JNK signaling pathway [27].