Frequency of the HIV-protective
CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C.
Mogamulizumab is a humanized monoclonal antibody directed against
CC chemokine receptor 4 (CCR4).
According to the company, Poteligeo is a monoclonal antibody that binds to a protein (called
CC chemokine receptor type 4 or CCR4) found on some cancer cells.
[18] Other studies also found that receptors of MCP-1,
CC chemokine receptor type 1 (CCR1) and
CC chemokine receptor type 2 (CCR2), were expressed on the ventral midbrain of humans.
We have reported that stimulation by fibronectin increases the release of CCL2 from activated microglia, and CCL2 stimulates the
CC chemokine receptor CCR2 of microglia resulting in the stimulation of P2X4R trafficking to the cell surface from lysosomes of microglia (38) (Fig.
Chang et al., "Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking
CC chemokine receptor 1," The Journal of Experimental Medicine, vol.
These cytokines stimulate the generation of eotaxin, which acting on
CC chemokine receptor 3 (CCR3) on eosinophilsthen stimulate the migration of eosinphils into the lung tissue.
Petrek, "
CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction," Immunology Letters, vol.
CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis.
The
CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/ lymphoma.
The
CC chemokine receptor 5 (CCR5) belongs to the trimeric guanine nucleotide-binding-protein-coupled seventransmembrane receptor superfamily, which comprises the largest superfamily of proteins in the body [8]; exerts its activity via G protein; and binds to the chemokines RANTES (CCL5), MIP-1[alpha] (CCL3), and MIP-1[beta] (CCL4) [9].