CCR3

(redirected from CC chemokine receptor)

CCR3

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for C-C-type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils, as well as in TH1 cells, TH2 cells and airway epithelial cells; it may contribute to the accumulation and activation of eosinophils and other inflammatory cells in airways allergies, and is also an entry co-receptor for HIV-1.
References in periodicals archive ?
Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C.
Mogamulizumab is a humanized monoclonal antibody directed against CC chemokine receptor 4 (CCR4).
Poteligeo is a monoclonal antibody that binds to a protein (called CC chemokine receptor type 4 or CCR4) found on some cancer cells.
According to the company, Poteligeo is a monoclonal antibody that binds to a protein (called CC chemokine receptor type 4 or CCR4) found on some cancer cells.
[18] Other studies also found that receptors of MCP-1, CC chemokine receptor type 1 (CCR1) and CC chemokine receptor type 2 (CCR2), were expressed on the ventral midbrain of humans.
We have reported that stimulation by fibronectin increases the release of CCL2 from activated microglia, and CCL2 stimulates the CC chemokine receptor CCR2 of microglia resulting in the stimulation of P2X4R trafficking to the cell surface from lysosomes of microglia (38) (Fig.
Chang et al., "Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1," The Journal of Experimental Medicine, vol.
These cytokines stimulate the generation of eotaxin, which acting on CC chemokine receptor 3 (CCR3) on eosinophilsthen stimulate the migration of eosinphils into the lung tissue.
Petrek, "CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction," Immunology Letters, vol.
CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis.
The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/ lymphoma.
The CC chemokine receptor 5 (CCR5) belongs to the trimeric guanine nucleotide-binding-protein-coupled seventransmembrane receptor superfamily, which comprises the largest superfamily of proteins in the body [8]; exerts its activity via G protein; and binds to the chemokines RANTES (CCL5), MIP-1[alpha] (CCL3), and MIP-1[beta] (CCL4) [9].