SERPINH1

(redirected from CBP1)
Also found in: Acronyms.

SERPINH1

A gene on chromosome 11q13.5 that encodes a member of the serpin superfamily of serine proteinase inhibitors that localises to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone.

Molecular pathology
Anti-SERPINH1 autoantibodies occur in patients with rheumatoid arthritis. SERPINH1 expression may be a marker for cancer. Nucleotide polymorphisms may be linked to pre-term labour due to premature rupture of membranes.
References in periodicals archive ?
DRK1 null (DRK1[delta]), insertional mutants, and RNA interference-(RNAi-) silenced strains grow as hyphae at 37[degrees]C instead of yeast, fail to upregulate yeast-phase specific virulence factors such as BAD1 and CBP1, and are avirulent in a murine model of infection [62].
These transcription factors form an integrated network in which they directly bind and regulate a common set of core genes including those important for virulence such as CBP1 and YPS3 [68].
English et al., "Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 during H.