CBP

CREBBP

A gene on chromosome 16p13.3 that encodes a ubiquitously expressed protein involved in the transcriptional coactivation of various transcription factors. CREBBP acts as a scaffold to stabilise additional protein interactions with the transcription complex; it has intrinsic histone acetyltransferase activity, and acetylates both histone and non-histone proteins.

Molecular pathology
CREBBP mutations cause Rubinstein-Taybi syndrome (RTS); chromosomal translocations of CREBBP are associated with acute myeloid leukaemia.

CBP

Abbreviation for community-based practice.

prostatitis

(pros?ta-ti'tis) [? + itis, inflammation]

Inflammation of the prostate gland, usually as a result of infection.

acute bacterial prostatitis

Inflammation of the prostate, commonly associated with urinary tract infections caused by enterococci, staphylococci, or gram-negative bacteria such as Escherichia coli. It often is caused by reflux of urine resulting from an anatomical abnormality. Patients present with fever, chills, urethral discharge, pain on urination, difficulty voiding, malaise, myalgias, and discomfort in the perineal area; the prostate is soft, swollen, and tender on examination.

The causative organism is identified through a culture of prostatic secretions and is treated with an extended course of antibiotics. Narcotics and antispasmodics may be needed to relieve pain.

chronic abacterial prostatitis

Inflammation of the prostate gland, marked by dull, aching pain in the perineum, usually of long duration. Although this is the most common type of chronic prostatitis, its cause is unknown.

Synonym: chronic pelvic pain syndrome

chronic bacterial prostatitis

Abbreviation: CBP

Inflammation of the prostate caused by a long-standing bacterial infection that often develops insidiously; causative organisms include gram-negative bacteria and enterococci. Clinically, the patient may have mild to moderate low back pain, pain with urination, and perineal discomfort, or he may be asymptomatic. Patients may have a history of multiple urinary tract infections; bacteria can hide in the prostate, which resists penetration by antibiotics, and reinfect the urinary tract. Causal bacteria are identified by culture of prostatic secretions and urine. Treatment consists of ciprofloxacin or another fluoroquinolone antibiotic for 4 to 6 weeks. The long course is needed because of poor penetration into the prostate.

---

chronic bacterial prostatitis

Abbreviation: CBP

Inflammation of the prostate caused by a long-standing bacterial infection that often develops insidiously; causative organisms include gram-negative bacteria and enterococci. Clinically, the patient may have mild to moderate low back pain, pain with urination, and perineal discomfort, or he may be asymptomatic. Patients may have a history of multiple urinary tract infections; bacteria can hide in the prostate, which resists penetration by antibiotics, and reinfect the urinary tract. Causal bacteria are identified by culture of prostatic secretions and urine. Treatment consists of ciprofloxacin or another fluoroquinolone antibiotic for 4 to 6 weeks. The long course is needed because of poor penetration into the prostate.

See also: prostatitis

CBP

competitive protein binding.