CNR2

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CNR2

A gene on chromosome 1p36.11 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR2 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR2 may play a role in the inflammatory response, nociceptive transmission and in bone homeostasis. CNR2 is also a less preferred gene symbol for what is now designated as PCDHA6, see there.
References in periodicals archive ?
CB2 Insights has a mission to mainstream medical cannabis into traditional healthcare.
Like cannabis, other herbs activate the CB2 receptors, too.
Shares of CB2 remained flat at C$0.20 on the CSE and slipped 3.2% to C$0.15 on OTC Markets.
Subject to satisfactory due diligence and other customary closing conditions, CB2 Insights will acquire MedEval for a total consideration consisting of USD 150,000 in cash and 450,000 shares of CB2 with a deemed value of USD 225,000.
For CB2, [LgBiT-[beta]arr2.sub.TR382] gave a significantly higher signal (P = 0.0427, unpaired student's t test, see file S2 in the online Data Supplement).
The majority of the studies (21 studies) on cannabinoids and CINP in animal models evaluated the effects of agonists via CB1 and CB2 receptors (Table 3).
The best fitting value for the critical concentration of the ternary composites with CB1, CB2, and CNT were [[phi].sub.c] = 0.58 vol%, 0.20 vol%, and 0.17 vol% which are more than 8 times lower than [[phi].sub.c] = 5.0 vol%, 2.0 vol%, and 1.5 vol% for the single phase systems, respectively.
In the periphery, CB2 receptors are widely located on immune cells and therefore represent a target for influencing inflammatory pain processing.
A limited number of studies have assessed the presence cannabinoid receptors (CB1 and CB2) in renal neoplasms and even fewer have assessed the role, if any, of the ECS in carcinogenesis and cell proliferation of renal neoplasms.
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(2) When a fault occurs in line 2 to 4, the value of fault current provided by DG may exceed the instantaneous current setting value of CB2. To meet the requirement of protection selectivity, the instantaneous current setting value should be close to the maximum transient current in the case that the fault happens at the remote terminal of DC line 1.