CNR1

(redirected from CB1A)

CNR1

A gene on chromosome 6q14-q15 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR1 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR1 is also a less preferred gene symbol for what is now designated as PCDHA4, see there.
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References in periodicals archive ?
Control fibroblasts (75 cell lines) were obtained from 23 individuals undergoing surgery or with a nonmetabolic disease, 30 individuals with a suspected metabolic disorder other than homocystinuria (e.g., disorders of biotin or methylmalonic acid related metabolism, or thiamin transport) or a suspected remethylation defect, but in whom such defects were excluded by fibroblast assays; and 22 individuals with a confirmed inherited disorder other than homocystinuria (8 with 3-methylcrotonyl-CoA carboxylase, 2 with propionyl-CoA carboxylase, 2 with holocarboxylase synthetase, and 1 with [[Delta].sup.1]-pyrroline-5-carboxylase synthase deficiency; 6 with methylmalonic aciduria attributable to the mut[degrees] and 2 attributable to the cb1A defect; and 1 with a defect in collagen synthesis).
Two disorders ([mut.sup.0] and [mut.sup.-]) reflect a deficiency of the apoenzyme portion of the enzyme methylmalonylCoA mutase; three others (cb1A, cb1B, and cb1H) are associated with abnormalities of the adenosylcobalamin synthesis pathway.