CA12

(redirected from CAXII)

CA12

A gene on chromosome 15q22 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate various biological processes, including respiration, calcification, maintaining acid-base balance, bone resorption and producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. The CA12 product is a type-I membrane protein which is highly expressed in normal tissues, such as kidney, colon and pancreas.

Molecular pathology
CA12 is overexpressed in 10% of clear cell carcinomas of the kidney.
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References in periodicals archive ?
Ryuge et al., "CAXII is a serodiagnostic marker for lung cancer," PLoS ONE, vol.
Mboge et al., "Differential expression and function of CAIX and CAXII in breast cancer: a comparison between tumorgraft models and cells," PLoS ONE, 2018.
Whereas there are 16 types of CA isozymes (among them--CAI, II, III, VII, and XIII being cytoplasmic, CAIV, IX, XII, XIV, and XV--membrane-bound, CAVa--mitochondrial and Vb and CAVI, secreted), only the hypoxia-inducible CA isozymes, CAIX and CAXII, are known to promote tumor growth through regulating the pH in the tumor microenvironment [6] and to be tumor associated.
In addition to HIFs, the hypoxia-mediated overexpression of extracellular carbonic anhydrases, CAIV and CAXII, facilitates cancer cell survival and the maintenance of CSC function [96].
Kim et al (271) evaluated a set of immunohistochemical markers including Ki-67, CAIX, CAXII, p53, PTEN, gelsolin, EpCAM, and vimentin in combination with established parameters.
Kim et al (148) evaluated a set of ICH markers, including Ki-67, CAIX, CAXII, p53, PTEN, gelsolin, EpCAM, and vimentin, in combination with established parameters.