CAV2

CAV2

A gene on chromosome 7q31.1 that encodes caveolin 2, the main scaffolding protein of the inner surface of caveolae (small invaginations of plasma membranes). Caveolin 2 is involved in essential cellular functions, including signal transduction, lipid metabolism, control of cell growth and apoptosis; it may function as a tumour suppressor.
References in periodicals archive ?
Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm.
Zhou, "Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins," Neuron, vol.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2 PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11 KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2 MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
Caveolins like CAV2 and CAV3 act as scaffolding proteins within caveolar membranes that interact directly with G-protein alpha subunits and can functionally regulate their activity.
Cav2.1 channels control multivesicular release by relying on their distance from exocytotic Ca2+ sensors at rat cerebellar granule cells.
SCA6 is correlated with a mutation in the voltage-dependent calcium channel P/Q type, alpha 1a subunit on the 19p13 chromosome (CACNA1A; CaV2.1).
A security code (CAV2) is set for each card to ensure secure payment for online shopping.
With regard to the functional significance of CB1 in autonomic ganglia, the voltage-dependent modulation of natively expressed N-type Ca+2 (CaV2.2) channels has been shown following extracellular application of 2-AG in sympathetic neurons heterologously expressing CB1 receptor (Won et at., 2009).
PRKCZ (potein kinase C, zeta), EDNRB (endothelin receptor type B), CDK5 (cell division protein kinase 5), and CACNA1A (cav2.1 P/Q voltage-dependent calcium channel) were related to nervous system diseases.
In previous studies, David Adams and colleagues from RMIT University in Melbourne showed that Vc1.1 also acts through GABAB receptors to inhibit a second, mysterious class of neuronal VGCCs that have been implicated in pain signaling but have not been well understood-R-type (Cav2.3) channels.