CAV-1

CAV-1

Abbreviation for canine adenovirus 1.
References in periodicals archive ?
The disease is also known to exist among wild canids in Canada, and the November 2012 issue of the Canadian Veterinary Journal cited a case of an 11-week-old Alaskan Husky who had been kept outdoors in the Yukon, where infectious canine hepatitis is considered endemic in the wildlife; on postmortem, the puppy tested positive for CAV-1.
Titers showed antibodies to CAV-1, and a necropsy confirmed the diagnosis.
A vaccine for CAV-1 fell out of use in the 1970s because one out of 500 vaccinated dogs developed "blue eye," an occular discoloration that resulted from a hypersensitivity to the vaccine.
Because CAV-2 immunity also covers CAV-1, those dogs are naturally protected against both.
For example, show dogs who are not vaccinated for CAV-1 will very likely become naturally immunized against it when CAV-2 infects them, as respiratory viruses are common in that kind of environment.
CAV-1 tem afinidade por celulas endoteliais e celulas hepaticas, esta presente em tecidos e em fluidos corporais e e excretado pela urina (HODGMAN & LARIN, 1953).
Rotineiramente o diagnostico de HIC e feito pela associacao entre sinais clinicos, lesoes macro e microscopicas, porem, outros metodos sao utilizados para confirmar a presenca do CAV-1 nos tecidos, como, por exemplo, a imunoistoquimica (IHQ), a tecnica reacao em cadeia da polimerase (PCR) e o isolamento viral (CHOUINARD et al.
O objetivo deste estudo foi detectar o antigeno de CAV-1 em tecidos de caes acometidos por HIC, procurando associar esses achados ao curso clinico da doenca.
A imunomarcacao do CAV-1 nos diversos tecidos demonstra a disseminacao do virus pelo organismo, principalmente afetando as celulas endoteliais.