Accordingly, there is a search for potential alternative markers for the diagnosis of PCa, one of which is caveolin-1 (CAV-1), a glycoprotein.
The purpose of the present study was to compare the CAV-1 levels of patients diagnosed with prostate cancer to their PSA results in order to evaluate if CAV-1 promises to be an alternative marker for PSA.
Caveolin-1 (Cav-1), a 22-kD protein of 178 amino acids and a member of the caveolin family (Cav-1, 2, and 3), is the highly conserved and essential component of caveolae .
Dysregulation of Cav-1 has been associated with several human malignancies including GC.
Our previous studies have confirmed that RSBFL can obviously improve the morphology and density of dendritic spines, promote the expression of CAV-1
, and suppress excessive abnormal phosphorylation of Tau protein in hippocampal neurons .
, the major structural protein of caveolae, functions as scaffolding protein  regulating multiple physiological processes including caveola biogenesis, vesicular transport, cholesterol homeostasis, and signal transduction .
The disease is also known to exist among wild canids in Canada, and the November 2012 issue of the Canadian Veterinary Journal cited a case of an 11-week-old Alaskan Husky who had been kept outdoors in the Yukon, where infectious canine hepatitis is considered endemic in the wildlife; on postmortem, the puppy tested positive for CAV-1
. As for this summer's New England
Canine adenovirus (CAV) can be grouped into two distinct but related serotypes, CAV-1
and CAV-2, based on serological tests  and molecular analyses [2-4].
For the first time, researchers from Jefferson's Kimmel Cancer Center show that loss of the tumor suppressor protein Caveolin-1 (Cav-1
) induces mitochondrial oxidative stress in the stromal micro-environment, a process that fuels cancer cells in most common types of breast cancer.
tem afinidade por celulas endoteliais e celulas hepaticas, esta presente em tecidos e em fluidos corporais e e excretado pela urina (HODGMAN & LARIN, 1953).
The first member of the Cav family (including Cav-1
, Cav-2, and Cav-3), Cav-1
, is a 22kDa protein of 178 amino acids that plays an essential role in the regulation of the cellular cholesterol metabolism of various signalling molecules (Src-like kinases, H-Ras, endothelial nitric-oxide synthase, and G
As a key structural protein of caveolae domains, caveolin-1 (Cav-1
) participates in regulating blood-brain barrier (BBB) permeability, oxidative stress, and counteracting neuroinflammatory process [3, 4].