CASP4


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CASP4

A gene on chromosome 11q22.2-q22.3 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development. CASP4 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is highly expressed in the lung and spleen.
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Compared with scrambled siRNA, the expression of anti-apoptosis-related genes/proteins (BAG1, BCL-2, and TP73) increased while apoptosis-related genes/proteins (CASP1, LTBR, and CASP4) decreased in MMP-13-silenced cells [Figure 1]c and [Figure 1]d.{Figure 1}
The siRNA sequences were as follows: human casp1, 5'-GGUUCGAUUUUCAUUUGA G-3' and 5,-CUCAAAUGAAAAUCGAACC-3'; human casp4, 5'-UCUACACUAUAGUCCAGACCC-3' and 5'-GUCUGGACUAUAGUGUAGAUG-3'; human casp5, 5'-AUAGAACGAGCAACCUUGAC-3' and 5'-GUCAAGGUUGCUCGUUCUAU-3'.
The up-regulated genes include HIAP1, CRAF1, TRAF6, CASP1, CASP2, CASP3, CASP4, HPRT, GADD45, MCL-1, NIP1, BCL2L2, TRAP3, GSTP1, DAXX, PIG11, UBC, PIG3, PCNA, CDC10, JNK1 and RBP2.