CASP2


Also found in: Acronyms.

CASP2

A gene on chromosome 7q34-q35 that encodes a member of the cysteine-aspartic acid protease (caspase) family of proteins, which mediate apoptosis by proteolysis of specific protein substrates. CASP2 is involved in stress-induced cell death, cell cycle maintenance and tumour suppression.

Molecular pathology
CASP2 is upregulated in neurodegenerative disorders—e.g., Alzheimer's disease, Huntington's disease and temporal lobe epilepsy.
References in periodicals archive ?
Coefficient Symbol Name Function -0.596 BCL7A B-Cell CLL/Lymphoma F-actin cross- 7A linking protein -0.575 TRIM24 Tripartite Transcriptional motif-containing 24 coactivator interacting with nuclear receptors and coactivators; modulation of transcription of target genes -0.564 CASP2 Caspase 2, Apoptosis execution apoptosis-related cysteine peptidase RNA -0.563 ZNF397 Zinc finger protein DNA-dependent 397 transcriptional repressor -0.563 ING2 Inhibitor Of Growth Induction of Family.
For example, BAK1 and CASP2 are both pro-apoptotic and have been shown to induce apoptosis in vitro and in vivo in several cell types (Kumar 2009; Pataer et al.
Such is the core of cooperation in the CASP2 framework in each country, together with a number of parallel regional cooperation initiatives and activities.
Initiator caspases (CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them.
RESULTS: Androgen-dependent and - independent human prostate cancer cell lines (LNCaP and PC3, respectively), androgen-dependent and -independent murine prostate cancer cell lines (CASP2.1 and CASP1.1, respectively), as well as noncancerous human benign prostate hyperplasia BPH-1 cell line, were used in the study.