The second benchmark is CASP11 experimental targets which were generated by Zhang-Server and QUARK.
Benchmarking on the CASP11 hard dataset, 8 (66.7%) out of 12 K-means++ model1 have higher TM-score than SPICKER model1.
He et al., "Template-based protein structure prediction in CASP11 and retrospect of I-TASSER in the last decade," Proteins: Structure, Function and Bioinformatics, vol.
Benchmarking Deep Networks for Predicting Residue-Specific Quality of Individual Protein Models in CASP11
. Scientific Reports, 6, 19301.
Do the results of the study fit with other available evidence (CASP11
CASP1 and CASP11 certainly play a critical role in regulating neuroinflammation and are increased in chronic pain conditions [4, 38].
There is increasing evidence that CASP1, CASP6, and CASP11 activation is involved in microglia activation and the maturation of proinflammatory cytokines in inflammatory and neuropathic pain conditions [19, 38, 53, 63].