CASP1


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CASP1

A gene on chromosome 11q23 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development.

Molecular pathology
CASP1 mutations may play a role in Huntington’s disease.
References in periodicals archive ?
In addition, CD11b+ cells expressed approximately 40-fold more Casp1 and approximately 20-fold more Tlr4 than CD11b- cells (all p-values < 0.001; see Supplemental Material, Figure S2G and F, respectively).
cDNAs for human CASP1, CASP4, and CASP5 were obtained from Sino Biological Inc.
RESULTS: Androgen-dependent and - independent human prostate cancer cell lines (LNCaP and PC3, respectively), androgen-dependent and -independent murine prostate cancer cell lines (CASP2.1 and CASP1.1, respectively), as well as noncancerous human benign prostate hyperplasia BPH-1 cell line, were used in the study.
Stimulation of the P2X7R also elicits the production of IL-1[beta] and its maturation via CatS and CASP1 [36], which can further increase microglia activation via the interleukin receptor IL1R [37] and it is also a key contributor in the hyperexcitability of the nociceptive dorsal horn neurons [14].