CASP9

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CASP9

A gene on chromosome 1p36.21 that encodes a ubiquitous protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis. CASP9 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is processed by APAF1, an early step in the caspase activation cascade. It is highly expressed in the heart.
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Difference in the mRNA expression of genes related to beta- actin mRNA expres-sion was determined using real-time poly-merase chain reaction in HT-29 cells (p<0.05) HT-29 cells Gene Name Fold Regulation 1 Beta-actin 1 2 CCNDI -12.6527 * 3 p21 14.579 * 4 p53 2.0702 * 5 Casp-3 4.6072 * 6 Casp-9 1.0916 7 Casp-8 2.4713 * 8 Bax -1.296 9 Bcl-2 -2.5902 * 10 ATM -4.4324 * 11 ATR 1.394 12 CHECKI -1.6646 * 13 CHECK2 -1.7279 * 14 ERCCI -1.0277 15 URG-4 3.3917 * 16 CDK6 -6.3755 * CCNDI: cyclin Dl; CDK6: cyclin-dependent kinase 6; CASP-3: caspase-3; CASP-8: caspase-8; CASP-9: caspase-9; CHEK1: checkpoint kinase 1; CHEK2: checkpoint kinase 2; ERCCI: excision repair cross- complementing I; ATM: ataxia telengiectasia mutated; ATR: ataxia telengiectasia and rad-3 related.
LG exposure (LG) did not affect gene expression of IL-6, ICAM-1, and COX2 as well Casp-3, Casp-9, and CHOP.
In our study, exposure to LPS increases expression of both Casp-3 and Casp-9 as well as that of CHOP, while 1-hour pretreatment with LG blunted all proapoptotic factors to levels even lower than those observed in basal experimental conditions.