CASK


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Idioms, Encyclopedia, Wikipedia.

CASK

A gene on chromosome Xp11.4 that encodes a calcium/calmodulin-dependent serine protein kinase of the membrane-associated guanylate kinase (MAGUK) family, which are scaffold proteins located at synapses in the brain. CASK is involved in synaptic transmembrane protein anchoring and ion channel trafficking; contributes to neural development and regulating gene expression by interacting with the transcription factor TRB1; binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans; and may mediate a link between the extracellular matrix and the actin cytoskeleton with syndecan and the actin/spectrin-binding protein 4.1.
 
Molecular pathology
CASK mutations are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, as well as an X-linked form of mental retardation.
Mentioned in ?
References in periodicals archive ?
'Malaysia consumers are becoming more sophisticated with their palates and they have a precise palate for The Glenlivet 15-Year-Old which is why we thought it would be good to show them what a single cask of 15-year-old is like,' said Yong at a closed tasting for members of the press and The Guardians of The Glenlivet on Wednesday.
These bourbon casks will contain approximately 280 70cl bottles-worth of a new, heavily-peated (50ppm) Single Malt that will be the style of whisky produced at the Lagg Distillery.
When the American White Oak casks' work at the Distillery is done, their staves are shipped from Scotland back to the USA to Renovo's workshop in Oregon.
The casks are checked on twice per shift by security and once per shift by the operations department to make sure they haven't been tampered with.
What sets Cask & Ale apart from similar beer-centric places here is the food.
GlobalData's latest report "Spent Nuclear Fuel Dry Storage Casks, Update 2016 - Global Market Size, Market Volume, Market Share and Key Country Analysis to 2020" provides detailed information on the use of dry casks for the storage of SNF, and provides an in-depth analysis of the global and regional markets, as well as the individual markets of 12 major countries.
Steve said: "We are primarily a cask ale brewery, but as we grow our business Storr is winning new followers.
The majority of craft beer is not cask-conditioned and nor is there any reason to - cask conditioning is ideal for traditional low strength British ales but wouldn't necessarily improve a 9% imperial black IPA."
"Through the use of our sherry cask, we have created a significantly different whisky with a darker tone and a wonderful taste, an excellent way to celebrate our second anniversary.
It is aged in bourbon casks and Iain explains: "We have flavour from two places; the spirit, and the character within it, then we put it in the cask and let the cask add to character."
Sisson noted that cask conditioning is the traditional way of presenting draft beer.