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Manca et al., "Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer," Human Mutation, vol.
Yao et al., "Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21," Cellular Signalling, vol.
Chen, "The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer," Scientific Reports, vol.
Gao et al., "RETRACTED: the long noncoding RNA CASC2 inhibits tumorigenesis through modulating the expression of PTEN by targeting miR-18a-5p in esophageal carcinoma," Experimental Cell Research, vol.
Zhu et al., "Long noncoding RNA CASC2 predicts the prognosis of glioma patients and functions as a suppressor for gliomas by suppressing Wnt/[beta]-catenin signaling pathway," Neuropsychiatric Disease and Treatment, vol.
Zhao et al., "LncRNA CASC2 interacts with miR-181a to modulate glioma growth and resistance to TMZ through PTEN pathway," Journal of Cellular Biochemistry, vol.
In two different studies on renal cell carcinoma and glioblastoma, it has been shown that miR-21 targeted and suppressed the expression of the tumor suppressor lncRNA CASC2 (cancer susceptibility candidate 2) in an AGO2-dependent manner [105,106].
In theory, the [beta]-catenin pathway, frequently hyperactivated in cancers, could be effectively attenuated by simultaneous silencing of miR-21, miR-135b, and FTH1P3 together with restoring physiologic levels of GAS5, CASC2, and miR-224-5p.
He, "Down-regulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells," Molecular Medicine Reports, vol.