CARD11

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CARD11

A gene on chromosome 7p22 that encodes a protein which provides the signal needed for T-cell receptor (TCR)-mediated T-cell activation. CARD11 binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. It activates NF-kappa-B via BCL10 and IKK and stimulates BCL10 phosphorylation.
References in periodicals archive ?
Sun, "TCR signalingto NF-[kappa]B and mTORC1: Expanding roles of the CARMA1 complex," Molecular Immunology, vol.
In addition, interaction of DPP4 with caveolin-1 may form a complex consisting of DOO4, CARMA1, Bcl10, MALT1, and I[kappa]B kinase in the lipid rafts on T cell membrane, leading to the activation of NF-[kappa]B [30].
Uchiyama, T Yamochi et al., "Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1," The Journal of Biological Chemistry, vol.
Recognition of the participation of the CARMA-Bcl10-Malt1 (CBM) signalosome in vital processes in cells continues to emerge, including distinct roles of CARMA1 in immune cells and CARMA3 in epithelial/endothelial cells.
The assembly of the lipid raft-associated CARMA-Bcl10-MALT1 (CBM) signalosome involves CARMA1 in the immune cells and CARMA3 in nonimmune cells [23, 48, 49].
Tschopp, "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-[kappa]B activation," FEBS Letters, vol.
TCR dependent activation of NF-[kappa]B is mediated by a scaffold protein CARMA1, which belongs to the family of membrane associated guanylate kinases (MAGUK) [38-40].
Landry et al., "Differential requirement for CARMA1 in agonist-selected T-cell development," European Journal of Immunology, vol.
Alegre, "CARMA1 controls an early checkpoint in the thymic development of foxP3 + regulatory T cells," Journal of Immunology, vol.
Wang, "The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling," Seminars in Immunology, vol.
Pomerantz et al., "Phosphorylation of the CARMA1 linker controls NF-[kappa]B activation," Immunity, vol.
You et al., "CD3/CD28 costimulation-induced NF-[kappa]B activation is mediated by recruitment of protein kinase C-0, Bcl10, and I[kappa]B kinase to the immunological synapse through CARMA1," Molecular and Cellular Biology, vol.