In addition, interaction of DPP4 with caveolin-1 may form a complex consisting of DOO4, CARMA1, Bcl10, MALT1, and I[kappa]B kinase in the lipid rafts on T cell membrane, leading to the activation of NF-[kappa]B .
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Recognition of the participation of the CARMA-Bcl10-Malt1 (CBM) signalosome in vital processes in cells continues to emerge, including distinct roles of CARMA1 in immune cells and CARMA3 in epithelial/endothelial cells.
The assembly of the lipid raft-associated CARMA-Bcl10-MALT1 (CBM) signalosome involves CARMA1 in the immune cells and CARMA3 in nonimmune cells [23, 48, 49].
Tschopp, "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-[kappa]B activation," FEBS Letters, vol.
TCR dependent activation of NF-[kappa]B is mediated by a scaffold protein CARMA1, which belongs to the family of membrane associated guanylate kinases (MAGUK) [38-40].
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You et al., "CD3/CD28 costimulation-induced NF-[kappa]B activation is mediated by recruitment of protein kinase C-0, Bcl10, and I[kappa]B kinase to the immunological synapse through CARMA1," Molecular and Cellular Biology, vol.