CARD8


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CARD8

A gene on chromosome 19q13.33 that encodes a protein involved in apoptosis which is highly expressed in the lung, ovary, testis and placenta. CARD8 inhibits NF-kappa-B activation and regulates cell responses controlled by NF-kappa-B transcription factor. It may be part of the inflammasome, a protein complex that activates proinflammatory caspases.
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Many studies have uncovered the performance of the CARD8 gene polymorphism rs2043211 in autoimmune disorders, RA, CD, and IBD [13,14,42,43].
Rantapaa-Dahlqvist, "CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.
Ahmad et al., "TUCAN (CARD8) genetic variants and inflammatory bowel disease," Gastroenterology, vol.
For each SNP, patients were stratified according to their specific genotypes and these, respectively, were analyzed for the correlation of the frequencies of IL-1[beta] (rs16944), IL-18 (rs1946518), CARD8 (rs2043211), and NF[kappa]B-94 ins/del ATTG with various clinical and laboratory features such as age, gender, subtype, BM myeloma cell percentage, bone damage, WBC (white blood cell), hemoglobin, platelet, and clinical stage (DS and ISS stage) in MM patients (Table 4).
MM patients with the AA or AT genotype displayed significantly decreased expression of CARD8 mRNA compared to the TT genotype of the rs2043211 of CARD8 (P < 0.05; Figure 2(a)).
However, there was no association between the expression of IL-18 and rs2043211 of CARD8 (Figure 3(c)).