CARD16

CARD16

A gene on chromosome 11q22.3 that encodes a protein which downregulates procaspase-1/CASP1 activation by inhibiting the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release in response to lipopolysaccharides during inflammation. CARD 16 induces NF-kappa-B activation during the pro-inflammatory cytokine response; it inhibits CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death (but not ER stress-mediated cell death). It blocks CASP1 and CASP4 activation, possibly by preventing the interaction between CASP1 and RIPK2.

Molecular pathology
CARD16 is downregulated in patients with clinical Huntington’s disease.
References in periodicals archive ?
The "peptidase inhibitor activity" annotation contains 10 genes, including APP, CARD16, SERPINB2, BIRC6, SERPINB1, SLPI, SERPINB3, HSPA5, SERPINB13, and OVOS2.
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