CARD14

CARD14

A gene on chromosome 17q25 that encodes a protein which activates NF-kappa-B via BCL10 and IKK and stimulates the phosphorylation of BCL10. CARD 14 is expressed in the placenta.
References in periodicals archive ?
CARD14 expression in dermal endothelial cells in psoriasis.
New susceptibility loci for psoriasis have been identified, including RUNX3, TAGAP, and STAT3 involved in regulating T cell function, DDX58, engaged in INF-mediated antiviral responses, ZC3H12C with a role in macrophage activation, and CARD14 and CARM1 involved in NF-[kappa]B signaling [99, 121].
Palmoplantar pustulosis (PPP) is the most common type of localized PP in the palmoplantar regions.[sup][1] Recent studies have discovered several susceptibility genes for psoriasis, some of which, such as interleukin 36 receptor antagonist ( IL36RN ) and caspase recruitment domain family member 14 ( CARD14 ), are shared between PP and PsV.[sup][2],[3] Mutations of adaptor-related protein complex 1 sigma three subunits ( AP1S3 ) were also detected in GPP, PPP, and acrodermatitis continua of Hallopeau (ACH).[sup][1] These findings suggested that there might be common susceptible genes between PP and PsV.
For instance, mutations of IL36RN , CARD14 , and AP1S3 genes are associated with GPP.[sup][1],[2],[3] The IL36RN mutation was also detected in PsV patients, suggesting that IL36RN plays a role in the development of PsV and GPP.
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Bachelez emphasizes that mutations in IL36RN, CARD14, and AP1S3 in these groups of diseases lead to an enhanced inflammatory cascade in several cellular subtypes including keratinocytes, and to the recruitment and activation of neutrophils and macrophages (17).
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