CARD11

CARD11

A gene on chromosome 7p22 that encodes a protein which provides the signal needed for T-cell receptor (TCR)-mediated T-cell activation. CARD11 binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. It activates NF-kappa-B via BCL10 and IKK and stimulates BCL10 phosphorylation.
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demonstrated that biallelic inactivation of TOX and PRKCD was recurrently found in PCNSL but not in systemic DLBCL; additionally, 90% of all cases harbored mutations leading to activation of the NF-?B signaling pathway such as activating mutations of MYD88, CARD11 , and CD79 , and deletions of TNFAIP3 and TBL1XR1 , indicating that the activation of NF-?B signaling pathway is a key driver of lymphoma genesis in PCNSL.[sup][51] Bruno et al.
They also found that some genes were upregulated in the termination regulation and may have potential negative effect on the cell cycle and promotion of cell apoptosis, such as the zinc finger protein gene (ZNF490) and caspase recruitment domain-containing protein 11 (CARD11) gene.
Abbreviations TGF-[beta]: Transforming growth factor beta TNF-[alpha]: Tumor necrosis factor-[alpha] TLR: Toll-like receptor MyD88: Myeloid differentiation factor 88 AP-1: Activating protein1 LPS: Lipopolysaccharide SOCS: Suppressors of cytokine signaling HGF: Hepatocyte growth factor TGF: Transforming growth factor EGF: Epidermal growth factor BAs: Bile acids NE: Norepinephrine VEGF: Endothelial growth factor IGF: Insulin-like growth factor ER: Estrogen receptors ZNF490: Zinc finger protein gene CARD11: Caspase recruitment domain-containing protein 11 ECM: Extracellular matrix S1P: Sphingosine-1-phosphate SK2: Sphingosine kinase 2 MSC: Mesenchymal stem cells DLS: Decellularized liver scaffold G-CSF: Granulocyte-colony stimulating factor.
23 October 2014 - US cancer genetic testing service provider NeoGenomics Inc (NASDAQ:NEO) disclosed Thursday the launch of new tests for the detection of mutations in the Bruton tyrosine kinase (BTK) and PLC-gama2 genes for predicting acquired resistance to BTK inhibitors, as well as the launch of a lymphoma profiling test predicting susceptibility to BTK inhibitors and testing for mutations in CXCR4, CD79B, MYD88, and CARD11 genes in various types of lymphoma.
En los LBDCG ABC se encuentran alteraciones en los genes que codifican para el complejo de senal CBM, que incluyen CARD11, BCL10, MALT1 y que tambien hacen parte de la via de senal del receptor de la celula B: BCR; favoreciendo estimulacion de la via de senal NF-kB y alteraciones de la senal para el BCR.
Faced with infection, the body's white blood cells are commanded by a protein - CARD11 - to either make more antibodies and white blood cells that attack the invader or to stand down and abort the mission.
The new research shows that CARD11 is under the control of GAKIN, another protein that supervises the directives given to each white blood cell.
Because of CARD11's importance in the decision-making process, it needs a regulator to make sure it turns off when it's no longer needed to avoid the risk of hyperactivity.
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Jennifer Martin (paired with Diego Castro) will share the title role in Eugene Ballet's `The Sleeping Beauty' Saturday and Sunday at the Hult.DEPARTMENTS Music3 Wild Card11 Screen15 Calendar23 LISTINGS Now Showing21 Stage25 Art Exhibits26 Concerts27