EPHB2

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EPHB2

A gene on chromosome 1p36.1-p35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB2 functions in axon guidance during development, guiding commissural axons and forming a major interhemispheric connection between the two temporal lobes of the cerebral cortex. EPHB2 is also involved in the guidance of contralateral inner ear efferent growth cones at the midline, and of retinal ganglion cell axons to the optic disk. It also regulates dendritic spines development and maturation, and it stimulates the formation of excitatory synapses.

Activation of EPHB2 by EFNB1 abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. EPHB2 also controls other aspects of development, including angiogenesis, palate development, as well as inner ear development by regulating endolymph production. It may act as a tumour suppressor.

Molecular pathology
Defects in EPHB2 have been linked to prostate cancer.
References in periodicals archive ?
anthracis Plasmid gene (CapB) and four (0.20%, 4/1985) were positive based on CT value for B.
In the right kidney, the CrPB of the RA was present in 101 specimens (83.5 %), whereas the CaPB was observed in 119 cases (98.3 %) (Fig.
Abbreviations CAPB: Cocamidopropyl betaine CHX: Chlorhexidine CPC: Cetylpyridinium chloride EtOH: Ethanol PEG: Pegylated hydrogenated castor oils SDS: Sodium dodecyl sulfate SF: Sodium fluoride.
Neither the Blanchard-type indicator nor changes in the CAPB are perfect measures of discretionary fiscal policymaking.
The baseline standard of a 4.5 percentage point reduction in the ratio of debt to potential GDP indentifies 21 successful consolidations using the CAPB method and four successful consolidations using the Action-Based method.
The S1 indicator shows the permanent adjustment to the cyclically-adjusted primary balance (CAPB) that is needed to reach a gross debt ratio of 60% of GDP (i.e.
According to this definition, a fiscal consolidation episode: * Starts if the cyclically adjusted primary balance (CAPB) improves by at least one percentage point of potential GDP in one year or in two consecutive years with at least 1/2 percentage point improvement occurring in the first of the two years.
The pXO2 plasmid contains the genes capA, capB, and capC, necessary for capsule formation (6).
Los sitios con mayor rendimiento y productividad, son los de menor edad y los que se aglutinan dentro del escenario con condiciones de crecimientos altos en pendientes bajas (CAPB).
Contract notice: mission tracking-animation technical assistance devices for the improvement of the old private park of the capb.P.
Glossary ALMPs Active labour market policies ATO Australian tax office BIS Basic income support CAPB Cyclically-adjusted primary balance DIT Dual income tax ECB European Central Bank EPL Employment protection legislation EMU European Monetary Union ETK Finnish Centre for Pensions FIN-FSA Finnish Financial Supervisory Authority GDP Gross domestic product HECS Australia's higher education contribution scheme HELP Higher education loan programme ICT Information and communication technology KELA Social insurance institution LAFOS Labour force service centres LMS Labour market support MEE Ministry of Employment and the Economy PES Public Employment Service R&D Research and development SATA Social Security Reform Committee SGP Stability and Growth Pact VAT Value added tax Notes