AZU1

(redirected from CAP37)

AZU1

A gene on chromosome 19q13.3 that encodes an azurophil granule protein of the serine protease family (but is not itself a serine protease), which has monocyte chemotactic and antibacterial activity, and acts as an important multifunctional inflammatory mediator. The genes encoding the AZU1 protein product, neutrophil elastase 2 and proteinase 3, are in a cluster at chromosome 19pter, and all three are expressed and packaged together into azurophil granules during neutrophil differentiation.
References in periodicals archive ?
GORDON D'ARCY Aged 35 the centre gave up playing after 2015 World Cup having won 82 cap37 in late 2011
Miller, "Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation," The Journal of Immunology, vol.
Pereira, "CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers," Microvascular Research, vol.
A study on their morphologic distribution and expression of CAP37. Pathol Res Pract 2010; 206:314-317
In the presence of cytochalasin D, the secretion of fMLP-treated neutrophils became enriched with the primary granule bactericides (such as MPO, cathepsin G, proteinase 3, CAP37, azurocidin, and HNP 1-3 or defensins 1-3), but the tertiary granule component MMP-9 did not fall in the number of major proteins (Figure 4(b), Table 1).