TRAF3

(redirected from CAP1)
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TRAF3

A gene on chromosome 14q32.32 that encodes TNF receptor-associated factor 3, which regulates NF-kappaB kinase and MAP kinase activation, plays a central role in regulating B-cell survival, and is part of signalling pathways leading to cytokine and interferon production. TRAF3 is required for normal antibody isotype switching from IgM to IgG, and it plays a role in T-cell dependent immune responses as well as antiviral responses. It is an essential constituent of several E3 ubiquitin-protein ligase complexes and may promote Lys-63-linked ubiquitination of target proteins. It inhibits NF-kappaB activation in response to LTBR stimulation, as well as TRAF2-mediated NF-kappaB activation, and it downregulates proteolytic processing of NFKB2 and NF-kappaB activation. It promotes ubiquitination and proteasomal degradation of MAP3K14.
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Expression of FLG, LEKTI, caspase14, KLK7, KLK5, matriptase, and CAP1 proteins was evaluated by Western blotting.
As shown in [Figure 1], FLG, LEKTI, and caspase14 expressions were significantly decreased, whereas matriptase, CAP1, KLK5, and KLK7 expressions were increased in acute AD lesions, as compared to normal controls.
Proteases, such as KLK5 and 7,[sup][9],[10],[11] matriptase,[sup][12] CAP1,[sup][12] and caspase-14[sup][13] can enhance FLG degradation process.
FLG is the key protein for maintaining normal epidermal barrier integrity and stratum corneum hydration.[sup][21] Many proteases are involved in this complex processing.[sup][14] The precursor pro-FLG is dephosphorylated with increasing calcium concentration and proteolytically cleaved by proteases, such as matriptase,[sup][22] CAP1,[sup][23] KLK7, and KLK5[sup][24] to release FLG protein during keratinocyte differentiation.
[p.sub.8] = [e.sup.U1(War)]/[e.sup.U1(War)] + [e.sup.U1(Cap1)];
Also, the authors argue that the degree of capital movement can be captured by either CAP1 or CAP2.
FTR1 CAP1 PLB1 IGS A1M R265 4 ([dagger]) 2 ([dagger]) 1 ([dagger]) 1 ([dagger]) A1M R272 4 3 ([double 2 ([double 2 ([double dagger]) dagger]) dagger]) A5M R57 4 2 1 1 A5M F738 4 2 1 1 KB7092 4 2 1 1 KB11765 4 2 1 1 KB2045 4 2 1 1 KB13866 4 2 1 1 KB11377 4 2 1 1 KB14489 4 2 1 1 KB14735 4 2 1 1 KB11632 4 2 1 1 A6M R38 9 4 # 1 3 ([paragraph]) ([paragraph]) * RFLP, restriction fragment length polymorphism; VI, Vancouver Island; LM, British Columbia lower mainland; GI, Gulf Islands; WA, northern Washington, USA; OR, Oregon, USA.