CAMKK1

CAMKK1

A gene on chromosome 17p13.2 that encodes a calcium/calmodulin-dependent serine/threonine protein kinase, which mediates many of calcium’s second messenger effects. CAMKK1 is part of a putative calcium-triggered signalling cascade involved in various cellular processes: it phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4; promotes cell survival by phosphorylating AKT1/PKB, which inhibits pro-apoptotic BAD/Bcl2-antagonist of apoptosis; and regulates apoptosis.
References in periodicals archive ?
Mayorga, "A novel role for CAMKK1 in the regulation of the mesenchymal stem cell secretome," Stem Cells Translational Medicine, vol.
Gene Product Capn3 NM_007601 Calpain 3 S100a3 NM_011310 S100 calcium binding protein A3 Camkk1 NM_018883 Calcium/calmodulin-dependent protein kinase kinase 1 Efcab4a NM_001025103 EF-hand calcium binding domain 4A alpha polypeptide 7 Pcdhb11 NM_053136 Protocadherin beta 11 Calr NM_00759 Calreticulin Gene Symbol Fold Change p-Value Capn3 +1.5 0.03 S100a3 +1.4 0.03 Camkk1 +1.2 0.01 Efcab4a +1.4 0.04 Pcdhb11 -2.2 0.004 Calr -1.2 0.04 Table 4.