CAMKK1 | definition of CAMKK1 by Medical dictionary
CAMKK1 A gene on chromosome 17p13.2 that encodes a calcium/calmodulin-dependent serine/threonine protein kinase, which mediates many of calcium’s second messenger effects. CAMKK1 is part of a putative calcium-triggered signalling cascade involved in various cellular processes: it phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4; promotes cell survival by phosphorylating AKT1/PKB, which inhibits pro-apoptotic BAD/Bcl2-antagonist of apoptosis; and regulates apoptosis.
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References in periodicals archive
Mayorga, "A novel role for CAMKK1
in the regulation of the mesenchymal stem cell secretome," Stem Cells Translational Medicine, vol.
Upstream it is regulated predominantly by LK[beta]1, CaMKK1
, and raised AMP: ATP.
Gene Product Capn3 NM_007601 Calpain 3 S100a3 NM_011310 S100 calcium binding protein A3 Camkk1
NM_018883 Calcium/calmodulin-dependent protein kinase kinase 1 Efcab4a NM_001025103 EF-hand calcium binding domain 4A alpha polypeptide 7 Pcdhb11 NM_053136 Protocadherin beta 11 Calr NM_00759 Calreticulin Gene Symbol Fold Change p-Value Capn3 +1.5 0.03 S100a3 +1.4 0.03 Camkk1
+1.2 0.01 Efcab4a +1.4 0.04 Pcdhb11 -2.2 0.004 Calr -1.2 0.04 Table 4.