CAMK4

CAMK4

A gene on chromosome 5q21.3 that encodes a multifunctional serine/threonine protein kinase, which is part of the calcium-triggered CaMKK-CaMK4 signalling cascade and regulates, mainly by phosphorylation, the activity of transcription activators (e.g., CREB1, MEF2D, JUN and RORA). These activators play key roles in immune response, inflammation and memory consodilation. In the thymus, CAMK4 regulates the CD4/CD8 (double positive thymocytes) selection threshold during T-cell ontogeny; it also play a role in transcriptional regulation in lymphocytes, neurons and male germ cells, and is expressed in the brain, thymus, CD4 T-cells and in epithelial ovarian cancers.
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References in periodicals archive ?
Similar to the previous pathways discussed above, GNAS was the only up-regulated gene (expression value 0.573); while the other genes associated with these pathways are down-regulated (ATM, CAMK4, FNBPI, ITPR1, NAPEPLD, PIK3R1, PRKA, PRKCH, and RHOH).
Of note, also the CAMK4 kinase, which was experimentally shown to be involved in the regulation of antibody response [10], was included in the biomarker.
Fourth, the data on genetic evaluation for hypertension, such as CaMK4 , PLA2 , and GRKs ,[sup][5] were not available from the secondary data used for this study.
Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice.
Enhanced [Ca.sup.2+] flux has been a hallmark characteristic in SLE patients and recent studies have demonstrated the involvement of calcium/calmodulin-dependent protein kinase IV (CaMK4) in the pathogenesis of SLE [72, 73].
Sorriento et al., "CaMK4 gene deletion induces hypertension," Journal of the American Heart Association, vol.