CAMK4A gene on chromosome 5q21.3 that encodes a multifunctional serine/threonine protein kinase, which is part of the calcium-triggered CaMKK-CaMK4 signalling cascade and regulates, mainly by phosphorylation, the activity of transcription activators (e.g., CREB1, MEF2D, JUN and RORA). These activators play key roles in immune response, inflammation and memory consodilation. In the thymus, CAMK4 regulates the CD4/CD8 (double positive thymocytes) selection threshold during T-cell ontogeny; it also play a role in transcriptional regulation in lymphocytes, neurons and male germ cells, and is expressed in the brain, thymus, CD4 T-cells and in epithelial ovarian cancers.
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