CAMK2D

CAMK2D

A gene on chromosome 4q26 that encodes the delta subunit of CAMK2, a calcium/calmodulin-dependent protein kinase which belongs to a calcium-triggered signalling cascade. It is involved in sarcoplamic reticulum Ca2+ transport in skeletal muscle; in neurons, CAMK2 participates in promoting dendritic spine and synapse formation and in maintaining synaptic plasticity, which enables long-term potentiation (LTP) and hippocampus-dependent learning.
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The phospholipase C beta 1 (PLCB1), PLCB4, adenylate cyclase 2 (ADCY2), ADCY8, calcium/calmodulin dependent protein kinase II beta (CAMK2B), CAMK2D, mitogen-activated protein kinase 11 (MAPK11), MAPK14, epidermal growth factor receptor (EGFR), growth factor receptor bound protein 2 (GRB2), Fyn proto-oncogene, Src family tyrosine kinase (FYN), and integrin subunit beta 5 (ITGB5) genes were involved in 12 significantly enriched pathways and accounted for 0.126% of the genetic variance for MY, 0.109% for FY, and 0.197% for AFC (Supplementary File SI).
miR-185 favours hypertrophic response by upregulating multiple genes in calcium signaling pathways, including [Ca.sup.2+]/CaM dependent protein kinase IId (Camk2d), sodium/calcium exchanger 1 (Ncx1), nuclear factor of activated T cells, and cytoplasmic calcineurin dependent 3 (Nfatc3) and downregulation of miR-185 can alleviate hypertrophy induced pathological changes in the heart [42].
These three genes, FSTL1 (follistatin-like 1), CAMK2D (calcium/ calmodulin-dependent protein kinase (CaM kinase) II delta) and KRT75 (keratin 75) (Figure 4), could reflect potential interaction of eggshell calcification and organic matrix formation.