The phospholipase C beta 1 (PLCB1), PLCB4, adenylate cyclase 2 (ADCY2), ADCY8, calcium/calmodulin dependent protein kinase II beta (CAMK2B
), CAMK2D, mitogen-activated protein kinase 11 (MAPK11), MAPK14, epidermal growth factor receptor (EGFR), growth factor receptor bound protein 2 (GRB2), Fyn proto-oncogene, Src family tyrosine kinase (FYN), and integrin subunit beta 5 (ITGB5) genes were involved in 12 significantly enriched pathways and accounted for 0.126% of the genetic variance for MY, 0.109% for FY, and 0.197% for AFC (Supplementary File SI).
Calcium/calmodulin-dependent protein kinase type II beta chain (CAMK2B) was differentially expressed in cisapride-, isoproterenol, and propranolol-treated cardiomyocytes from individual 1434.
ATP1A1, ATPase [Na.sup.+]/[K.sup.+] transporting subunit alpha 1; ATP1B1, ATPase [Na.sup.+]/[K.sup.+] transporting subunit beta 1; CALM3, calmodulin 3; CAMK2B, Calcium/calmodulin-dependent protein kinase type II beta chain; Cmax, maximum concentration in blood plasma; CV, coefficient of variation; DMSO, dimethyl sulfoxide; hERG, human ethera-go-go-related gene; ITPR2, inositol 1,4,5-trisphosphate receptor, type 2; iPSC, induced pluripotent stem cell; IVIVE, in vitro-to-in vivo extrapolation; PLN, phospholamban; KCNK1, potassium channel subfamily K member 1; PRKACA, catalytic subunit a of protein kinase A; RED, rapid equilibrium dialysis; RFU, relative fluorescence units
As shown in Table 2, several genes, including MMP9, CD44, COL1A1, COL1A2, CAMK2A, and CAMK2B, exhibited a high connectivity degree >25.
In addition, we also identified key genes, including MMP9, CD44, CDC42, COL1A1, COL1A2, CAMK2A, and CAMK2B, as potential target genes for diagnosing glioblastoma.
The combination of tetramethylpyrazine phosphate (TMPP) and Ginsenoside-Rb1 (Rb1) in [cTnT.sup.R141W] mouse model also obtained some benefit; the downregulated level of calmodulin 1 and calcium/calmodulin-dependent protein kinase II[beta] (Camk2b
) indicated that TMP might regulate [Ca.sup.2+]/CaM/CaMKII .
Gene symbol Gene name change 211869 DKK2 dickkopf homolog 2 1.9 592141 NFATC2 nuclear factor of activated T-cells, 1.8 cytoplasmic, calcineurin-dependent 2 599590 SOX17 SRY (sex determining region Y)-box 1.4 17 6347 LRP5 low density lipoprotein receptor- 1.3 related protein 5 525704 JUN v-jun sarcoma virus 17 oncogene 1.3 homolog 283565 FOSL1 fos-like antigen 1 1.2 351887 CAMK2B
calcium/calmodulin-dependent protein 1.2 kinase II beta 149413 PPP3CC protein phosphatase 3, catalytic 1.2 subunit, gamma isoforms (calcineurin A gamma) 94234 FZD1 frizzled homolog 1 0.8 591968 FZD4 frizzled homolog 4 0.8 524348 PRICKLE1 prickle-like 1 0.8 Gene annotations are from Unigene (http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=unigene).