CAMK2A

CAMK2A

A gene on chromosome 5q32 that encodes the alpha subunit of CAMK2, a calcium/calmodulin-dependent protein kinase which belongs to a calcium-triggered signalling cascade. It is involved in sarcoplamic reticulum Ca2+ transport in skeletal muscle; in neurons, CAMK2 participates in promoting dendritic spine and synapse formation and in maintaining synaptic plasticity, which enables long-term potentiation (LTP) and hippocampus-dependent learning.
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Intriguingly, a recent genetic study identified nonsense mutations within CAMK2A gene in patients with schizophrenia [72], further supporting possibility of CaMKII as an indispensable molecule to mediate pathophysiological conditions of schizophrenia.
A mutation of CAMK2A gene was found in patients with schizophrenia and it is also implicated in bipolar disorder [72, 73].
As shown in Table 2, several genes, including MMP9, CD44, COL1A1, COL1A2, CAMK2A, and CAMK2B, exhibited a high connectivity degree >25.
COL3A1, MMP9, CAMK2A, CD44, HTR2A, SV2B, GRIN2A, COL6A3, and SH3GL3 have been identified as significant genes in these pathways.
In addition, we also identified key genes, including MMP9, CD44, CDC42, COL1A1, COL1A2, CAMK2A, and CAMK2B, as potential target genes for diagnosing glioblastoma.
Several proteins were differentially expressed, which included karyopherin alpha 4 (KPNA4) overexpressed only in paralytic rabies, calcium calmodulin dependent kinase 2 alpha (CAMK2A) which was upregulated in paralytic rabies, and glutamate ammonia ligase (GLUL) which was overexpressed both in paralytic and encephalitic rabies.