CAMK4

(redirected from CAM kinase IV)

CAMK4

A gene on chromosome 5q21.3 that encodes a multifunctional serine/threonine protein kinase, which is part of the calcium-triggered CaMKK-CaMK4 signalling cascade and regulates, mainly by phosphorylation, the activity of transcription activators (e.g., CREB1, MEF2D, JUN and RORA). These activators play key roles in immune response, inflammation and memory consodilation. In the thymus, CAMK4 regulates the CD4/CD8 (double positive thymocytes) selection threshold during T-cell ontogeny; it also play a role in transcriptional regulation in lymphocytes, neurons and male germ cells, and is expressed in the brain, thymus, CD4 T-cells and in epithelial ovarian cancers.
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We theorized that a Src kinase inhibitor, in addition to hypothermia, would further attenuate the activation of CaM kinase IV and that the result might be less brain damage," explained lead author Panagiotis Kratimenos.
The authors concluded that hypothermia alone attenuated the over-activation of CaM kinase IV and improved neuropathology after hypoxia.