S100G

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S100G

A gene on chromosome Xp22.2 that encodes calbindin-D9K, a cytosolic vitamin D-dependent calcium-binding protein, which contains 2 active calcium-binding domains. Calbindin D9K’s expression correlates with calcium transport activity; it may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles.
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A complex mixture of different concentrations of synthetic complements, which included the antisense oligonucleotides specific for M13, Calb3, Cyp171a, Pp1b, and Hsd11b2 (sequences are given in Table 1), was mixed with oligonucleotides specific to GAPDH-5' and GAPDH-3' mRNA region (5'-CGTCAAGATCAAATGGGGTGAT GCT-3 and 5-ATCCTGGGCTACACT GAGGACCAGG-3', respectively), and a single-base mismatch for Hsd11b2 (mutation on the central region, 5'-TCATGAGACC ATcTATACCCTACC-3').
In Figure 3A, the titration curve of a biotinylated complementary oligonucleotide for Calb3 is shown for the comparison of the nonamplified and amplified signal.
The reproducibility of the assay is represented in Figure 5 with the determination of the expression levels of Calb3, an up-regulated gene, and Cyp17a1, a down-regulated gene, in independent samples.
The fluorescent signal corresponding to the transcript levels of Calb3 in control samples increased approximately 4-fold from 68 units to 234 units using 10 [micro]g cRNA, but the fluorescent signal of the sample derived from tissues exposed to EE in the high-dose group (10 [micro]g/kg/day) increased from 980 to 10,632 units by using the amplification step.