CALB1

CALB1

A gene on chromosome 8q21.3-q22.1 that encodes calbindin-D28K, a calcium-binding protein of the troponin C superfamily, which contains 4 active calcium-binding domains. Calbindin buffers cytosolic calcium and stimulates membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase; it is synthesised in the brain independent of vitamin D.

Molecular pathology
Cerebral neurones in Huntington disease are
calbindin-D28K depleted.
Mentioned in ?
References in periodicals archive ?
In FLX-treated mice, expression of Calb1, Tdo2, and Dsp, markers for mature granule cells, was greatly reduced in the DG.
Next, intracellular calcium ions are transported by calcium transport proteins, calbindinD9k (S100G) and calbindin-D28k (CALB1), to the b a solateral side of epithelial cells.
[Source:RefSeq mRNA;Acc:NM_001184752] ENSSSCG00000006125 Sus scrofa calbindin 1, 28kDa (CALB1), mRNA.