CA.1aj.9

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CA.1aj.9

A gene on chromosome 9p12 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. CA9 is a transmembrane protein and the only known tumour-associated carbonic anhydrase isoenzyme, and may be involved in cell proliferation and transformation.

Molecular pathology
CA9 is expressed in all clear-cell type renal cell carcinomas, but is not expressed in normal kidney or most other normal tissues.
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He ran 150 yards across No Man's Land to rescue a badly-wounded officer, dragging him back to safety and bandaging his wounds in the open under a hail of heavy German fire at Caix on the Somme.
The withdrawal was done under heavy enemy machine gun fire, and on 28th the battalion was again forced back to Caix, Cayeux and then Louvrechy.
Caix, "Relationships between geometry and kinematic characteristics in the temporomandibular joint," Computer Methods in Biomechanics and Biomedical Engineering, vol.
Carbonic anhydrase IX (CAIX) is a transmembrane protein that catalyzes the hydration of carbon dioxide to carbonic acid, modulating pH [20].
[2]: oxygen ([O.sub.2]) electrodes such as OxyLite; electron paramagnetic resonance (EPR); histological assessment with extrinsic biomarkers, mainly pimonidazole, and intrinsic biomarkers such as carbonic anhydrase IX (CAIX); blood [O.sub.2] level-dependent (BOLD) magnetic resonance imaging (MRI); and single photon emission tomography (SPECT) or PET with for instance hypoxia-targeting 2-nitroimidazole-based radiotracers [2,3].
van Steenbergen et al., "Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity," Molecular Therapy, vol.
Secades et al., "Clinically relevant HIF-1[alpha]-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation," Oncotarget, vol.
This was confirmed with immunohistochemical stain, which showed atypical cells to be positive for PAX8 (Figure 3(b)) and CAIX while negative for TTF-1.
The CAIX, PAX8, PAX2, CD10, and RCC demonstrate restricted expression in CCRCC but not in angiosarcomas.
Central arterial and haemodynamic parameters (cAIx and cSBP) can be estimated noninvasively using a good number of techniques.